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C8895

氯法齐明

Name: 氯法齐明
Brand: SIGMA

≥98% (TLC), powder, antimycobacterial rimonphenazine

别名:

N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine

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关于此项目

经验公式（希尔记法）:

C₂₇H₂₂Cl₂N₄

化学文摘社编号:

2030-63-9

分子量:

473.40

NACRES:

NA.77

PubChem Substance ID:

24893114

UNSPSC Code:

12352200

EC Number:

217-980-2

MDL number:

MFCD00056793

Form:

powder

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属性

产品名称

氯法齐明,

form

powder

Quality Segment

200

antibiotic activity spectrum

mycobacteria

mode of action

protein synthesis | interferes

originator

Novartis

SMILES string

CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5

InChI

1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+

InChI key

WDQPAMHFFCXSNU-BGABXYSRSA-N

说明

General description

Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.

Application

Clofazimine has been used:

for antimicrobial preparation
to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
to model drug-induced hepatic granulomatous inflammation
to study the in vivo cargo storage capacity of macrophages

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

This product is stored at room temperature.

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存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000539225

0000539224