C8895
氯法齐明
≥98% (TLC), powder, antimycobacterial rimonphenazine
别名:
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
产品名称
氯法齐明,
表单
powder
质量水平
抗生素抗菌谱
mycobacteria
作用机制
protein synthesis | interferes
创始人
Novartis
SMILES字符串
CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
InChI
1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
InChI key
WDQPAMHFFCXSNU-BGABXYSRSA-N
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一般描述
Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.
应用
Clofazimine has been used:
- for antimicrobial preparation
- to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
- to model drug-induced hepatic granulomatous inflammation
- to study the in vivo cargo storage capacity of macrophages
特点和优势
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
制备说明
This product is stored at room temperature.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
In vitro approaches for generation of Mycobacterium tuberculosis mutants resistant to bedaquiline, clofazimine or linezolid and identification of associated genetic variants
Ismail N, et al.
Journal of Microbiological Methods, 153(8), 1-9 (2018)
A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages
Keswani RK, et al.
Cytometry. Part A : the Journal of the International Society For Analytical Cytology, 87(9), 855-867 (2015)
Plumb's Veterinary Drug Handbook (2008)
An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver
Rzeczycki P, et al.
Pharmaceutical Research, 36(1), 3-3 (2019)
An Expandable Mechanopharmaceutical Device (1): Measuring the Cargo Capacity of Macrophages in a Living Organism
Rzeczycki P, et al.
Pharmaceutical Research, 36(1), 12-12 (2019)
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