C8988
8-（4-氯苯硫基）-2′-O-甲基腺苷- 3′,5′-环一磷酸 单钠 水合物
≥98% (HPLC), Epac or cAMP-GEF activator, powder
别名:
8-pCPT-2′-O-Me-cAMP
登录查看公司和协议定价
关于此项目
经验公式（希尔记法）:
C17H16N5O6ClPSNa · xH2O
CAS Number:
分子量:
507.82 (anhydrous basis)
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
Product Name
8-（4-氯苯硫基）-2′-O-甲基腺苷- 3′,5′-环一磷酸 单钠 水合物, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
protect from light
颜色
white
mp
235.5-237.5 °C (lit.)
溶解性
H2O: >10 mg/mL
储存温度
−20°C
SMILES字符串
O.[Na+].CO[C@@H]1[C@@H]2OP([O-])(=O)OC[C@H]2O[C@H]1n3c(Sc4ccc(Cl)cc4)nc5c(N)ncnc35
InChI
1S/C17H17ClN5O6PS.Na.H2O/c1-26-13-12-10(6-27-30(24,25)29-12)28-16(13)23-15-11(14(19)20-7-21-15)22-17(23)31-9-4-2-8(18)3-5-9;;/h2-5,7,10,12-13,16H,6H2,1H3,(H,24,25)(H2,19,20,21);;1H2/q;+1;/p-1/t10-,12-,13-,16-;;/m1../s1
InChI key
NVPSOXGMFVFZIS-IPBMGFFTSA-M
相关类别
生化/生理作用
天然cAMP的类似物，Epac或cAMP-GEF的强效和特异性膜透过活化剂，是环磷酸腺苷的一种新受体。
天然cAMP的类似物，由cAMP（Epac或cAMP-GEF）直接激活的交换因子的强效和特异性膜透过活化剂，是环磷酸腺苷的一种新受体
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
其他说明
光敏感
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Shuang Tao et al.
Journal of oncology, 2022, 5483523-5483523 (2022-07-12)
Chemoresistance poses a great hindrance in the treatment of breast cancer (BC). Interestingly, exosome (Exo)-mediated transfer of long noncoding RNAs (lncRNAs) has been reported to regulate chemoresistance in diverse diseases. We herein investigate the potential role of lncRNA metastasis-associated lung
Ana-Caroline Raulin et al.
STAR protocols, 4(1), 101976-101976 (2023-01-05)
Cholesterol is a structural component of cell membranes. Most cells are incapable of its catabolism, and intracellular cholesterol accumulation is linked to several disorders including cardiovascular and neurodegenerative diseases. Cholesterol efflux, essential to its metabolism, is dependent on acceptors such
Mengye Li et al.
Clinical and experimental pharmacology & physiology, 44(6), 686-692 (2017-03-21)
Recent papers have attributed arrhythmic substrate in murine RyR2-P2328S hearts to reduced action potential (AP) conduction velocities (CV), reflecting acute functional inhibition and/or reduced expression of sodium channels. We explored for acute effects of direct exchange protein directly activated by
Shingo Koinuma et al.
Journal of neurochemistry, 157(4), 1196-1206 (2020-11-07)
Intracellular signaling pathways that promote axon regeneration are closely linked to the mechanism of neurite outgrowth. TC10, a signaling molecule that acts on neurite outgrowth through membrane transport, is a member of the Rho family G proteins. Axon injury increases
Yang Wang et al.
Molecular brain, 15(1), 35-35 (2022-04-25)
RUN and FYVE domain-containing 3 (Rufy3) is a well-known adapter protein of a small GTPase protein family and is bound to the activated Ras family protein to maintain neuronal polarity. However, in experimental subarachnoid hemorrhage (SAH), the role of Rufy3
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持