C8988
8-（4-氯苯硫基）-2′-O-甲基腺苷- 3′,5′-环一磷酸 单钠 水合物
≥98% (HPLC), Epac or cAMP-GEF activator, powder
别名:
8-pCPT-2′-O-Me-cAMP
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关于此项目
经验公式（希尔记法）:
C17H16N5O6ClPSNa · xH2O
化学文摘社编号:
分子量:
507.82 (anhydrous basis)
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
产品名称
8-（4-氯苯硫基）-2′-O-甲基腺苷- 3′,5′-环一磷酸 单钠 水合物, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
protect from light
颜色
white
mp
235.5-237.5 °C (lit.)
溶解性
H2O: >10 mg/mL
储存温度
−20°C
SMILES字符串
O.[Na+].CO[C@@H]1[C@@H]2OP([O-])(=O)OC[C@H]2O[C@H]1n3c(Sc4ccc(Cl)cc4)nc5c(N)ncnc35
InChI
1S/C17H17ClN5O6PS.Na.H2O/c1-26-13-12-10(6-27-30(24,25)29-12)28-16(13)23-15-11(14(19)20-7-21-15)22-17(23)31-9-4-2-8(18)3-5-9;;/h2-5,7,10,12-13,16H,6H2,1H3,(H,24,25)(H2,19,20,21);;1H2/q;+1;/p-1/t10-,12-,13-,16-;;/m1../s1
InChI key
NVPSOXGMFVFZIS-IPBMGFFTSA-M
相关类别
生化/生理作用
天然cAMP的类似物，Epac或cAMP-GEF的强效和特异性膜透过活化剂，是环磷酸腺苷的一种新受体。
天然cAMP的类似物，由cAMP（Epac或cAMP-GEF）直接激活的交换因子的强效和特异性膜透过活化剂，是环磷酸腺苷的一种新受体
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
其他说明
光敏感
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Andrzej J Chruscinski et al.
PloS one, 8(12), e82164-e82164 (2013-12-18)
β-adrenergic receptors (β-ARs) are model G-protein coupled receptors that mediate signal transduction in the sympathetic nervous system. Despite the widespread clinical use of agents that target β-ARs, the signaling pathways that operate downstream of β-AR stimulation have not yet been
Ángeles Domínguez-Soto et al.
Scientific reports, 7(1), 14761-14761 (2017-11-09)
Peripheral serotonin (5-hydroxytryptamine, 5-HT) regulates cell growth and differentiation in numerous cell types through engagement of seven types of cell surface receptors (HTR1-7). Deregulated 5-HT/HTR levels contribute to pathology in chronic inflammatory diseases, with macrophages being relevant targets for the
Ana-Caroline Raulin et al.
STAR protocols, 4(1), 101976-101976 (2023-01-05)
Cholesterol is a structural component of cell membranes. Most cells are incapable of its catabolism, and intracellular cholesterol accumulation is linked to several disorders including cardiovascular and neurodegenerative diseases. Cholesterol efflux, essential to its metabolism, is dependent on acceptors such
Shuang Tao et al.
Journal of oncology, 2022, 5483523-5483523 (2022-07-12)
Chemoresistance poses a great hindrance in the treatment of breast cancer (BC). Interestingly, exosome (Exo)-mediated transfer of long noncoding RNAs (lncRNAs) has been reported to regulate chemoresistance in diverse diseases. We herein investigate the potential role of lncRNA metastasis-associated lung
Mengye Li et al.
Clinical and experimental pharmacology & physiology, 44(6), 686-692 (2017-03-21)
Recent papers have attributed arrhythmic substrate in murine RyR2-P2328S hearts to reduced action potential (AP) conduction velocities (CV), reflecting acute functional inhibition and/or reduced expression of sodium channels. We explored for acute effects of direct exchange protein directly activated by
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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