C9033
ββ-氯-L-丙氨酸 盐酸盐
Alanine aminotransferase inhibitor
别名:
(R)-2-Amino-3-chloropropanoic acid, 3-Chloro-L-alanine
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关于此项目
经验公式（希尔记法）:
C3H6ClNO2 · HCl
化学文摘社编号:
分子量:
160.00
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Application
ββ-氯-L-丙氨酸盐酸盐已用于：
- 作为底物，用于研究酪氨酸酚裂解酶稳态动力学
- 研究Ly-1淋巴细胞中的丝氨酸棕榈酰转移酶抑制和细胞毒性
- 在小麦胚无细胞蛋白合成系统中作为丙氨酸转氨酶抑制剂
Biochem/physiol Actions
ββ-氯-L-丙氨酸盐酸盐是丙氨酸氨基转移酶(ALAT)抑制剂。抑制ALAT可导致肺癌进展抑制。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
A novel way of amino acid-specific assignment in 1 H-15 N HSQC spectra with a wheat germ cell-free protein synthesis system
Morita EH, et al.
Journal of Biomolecular Nmr, 30(1), 37-45 (2004)
Oxytetracycline have the therapeutic efficiency in CD133+ HCC population through suppression CD133 expression by decreasing of protein stability of CD133
Song Y, et al.
Scientific Reports, 8(1), 16100-16100 (2018)
Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells: a novel evaluation system using an SPT-defective mammalian cell mutant
Hanada K, et al.
Biochemical Pharmacology, 59(10), 1211-1216 (2000)
Inhibition of alanine aminotransferase (ALAT) in silico and in vivo promotes mitochondrial metabolism to impair malignant growth
Beuster G, et al.
The Journal of Biological Chemistry, jbc-M110 (2011)
Affinity labeling of alanine aminotransferase by 3-chloro-L-alanine.
Y Morino et al.
The Journal of biological chemistry, 254(2), 279-285 (1979-01-25)
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