C9369
CCT007093
≥98% (HPLC), powder, yellow
别名:
(2E,5E)-2,5-Bis(2-thienylmethylene)-cyclopentanone
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关于此项目
经验公式（希尔记法）:
C15H12OS2
化学文摘社编号:
分子量:
272.39
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder, yellow
assay
≥98% (HPLC)
form
powder, yellow
solubility
DMSO: >3 mg/mL
storage temp.
2-8°C
SMILES string
O=C1\C(CC\C1=C/c2cccs2)=C\c3cccs3
InChI
1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+
InChI key
KPFZCKDPBMGECB-WGDLNXRISA-N
Application
CCT007093 has been used as a wild-type p53-induced phosphatase (Wip1) inhibitor to study its effect on skin keratinocytes, under ultra-violet (UV) stress conditions. It has also been used as a Wip1 inhibitor in time course inhibition assay to evaluate the effect of Wip1 inhibition on expression of AKT serine/threonine kinase 1(Akt1) and glycogen synthase kinase-3β (GSK-3β)and the phosphorylation of GSK-3β at serine 9 (Ser9) and Akt at Ser473.
Biochem/physiol Actions
CCT007093 inhibits the growth of cancer cell lines (MCF-7, KPL-1, and MCF-3B) that overexpress protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D). It induces cancer cell death via the activation of p38 kinase activity.
CCT007093 is an effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines.
CCT007093 is an effective protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) inhibitor that selectively reduces viability of human tumour cell lines.
Features and Benefits
This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves