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C9377

鹅去氧胆酸

Name: 鹅去氧胆酸
Brand: SIGMA

别名:

3α，7α-二羟基-5β-胆汁酸, 5β-胆酸-3α，7α-二醇, 鹅去氧胆酸

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关于此项目

经验公式（希尔记法）:

C₂₄H₄₀O₄

化学文摘社编号:

474-25-9

分子量:

392.57

UNSPSC Code:

12352106

NACRES:

NA.25

PubChem Substance ID:

24893153

EC Number:

207-481-8

Beilstein/REAXYS Number:

3219887

MDL number:

MFCD00064142

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description

anionic

Quality Level

200

form

powder

mol wt

392.57 g/mol

technique(s)

protein quantification: suitable

CMC

(3)

mp

165-167 °C (lit.)

functional group

carboxylic acid

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1

InChI key

RUDATBOHQWOJDD-BSWAIDMHSA-N

Gene Information

human ... CYP1A2(1544), NR1H4(9971)

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General description

鹅去氧胆酸是胆固醇在肝脏中合成的胆汁酸。

Application

鹅去氧胆酸已被用于一项评估其作为脑腱黄色瘤病（CTX）的长期替代疗法的效果的研究中。它也被用于一项研究其对回肠造口患者小肠吸收胆汁酸的影响的研究中。

Biochem/physiol Actions

胆汁酸

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000498789

0000490370

0000461548

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A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits.

M O Osman et al.

Gut, 43(2), 232-239 (1999-04-06)

Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis. To define the role of IL-8 in acute pancreatitis by neutralising its effects with a

Gallstone dissolution in man using chenodeoxycholic acid

Bell, G., et al.

Lancet, 300, 1213-1213 null

Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids.

A Stiehl et al.

Gastroenterology, 98(2), 424-428 (1990-02-01)

The effects of ursodeoxycholic acid and chenodeoxycholic acid on the small-intestinal absorption of endogenous bile acids were studied in patients with ileostomies who served as a model to investigate small-intestinal absorption in humans. In the control period, the eight patients

Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5.

Wei Zhou et al.

Journal of biomolecular screening, 15(5), 488-497 (2010-05-08)

Dietary long-chain fatty acid (LCFA) uptake across cell membranes is mediated principally by fatty acid transport proteins (FATPs). Six subtypes of this transporter are differentially expressed throughout the human and rodent body. To facilitate drugs discovery against FATP subtypes, the

Isolation and characterization of hydrophobic polypeptides in human bile.

M Stark et al.

European journal of biochemistry, 266(1), 209-214 (1999-10-29)

Polypeptides were isolated from human bile by extraction with chloroform/methanol, followed by reversed-phase chromatography in methanol/ethylene chloride and gel filtration in chloroform/methanol. Peptides were characterized by SDS/PAGE, sequence analysis and matrix-assisted laser desorption ionization/time-of-flight mass spectrometry. This identified haemoglobin alpha

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实验方案

HPLC Separation of Bile Acids with Ascentis Express C18

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

全球贸易项目编号

货号	GTIN
C9377-25G	04061833530566
C9377-100MG	04061833530559
C9377-5G	04061833530573

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