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Merck
CN

C9538

辅酶 Q10

≥98% (HPLC), powder, antioxidant

别名:

CoQ10, Q-10, 辅酶Q10, 辅酶Q50

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关于此项目

经验公式（希尔记法）:
C59H90O4
化学文摘社编号:
303-98-0
分子量:
863.34
NACRES:
NA.77
PubChem Substance ID:
24893170
UNSPSC Code:
12352200
EC Number:
206-147-9
MDL number:
MFCD00042919
Beilstein/REAXYS Number:
1900141

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产品名称

辅酶 Q10, ≥98% (HPLC)

InChI key

ACTIUHUUMQJHFO-UPTCCGCDSA-N

InChI

1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

SMILES string

O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O

assay

≥98% (HPLC)

form

powder

color

yellow to dark orange

mp

49 °C

application(s)

cell analysis

storage temp.

−20°C

Quality Level

200

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相关类别

Application

辅酶Q10（CoQ10）已被用于：
  • 作为一种生物活性化合物，在体外研究其免疫调节特性
  • 高效液相色谱的标准品
  • 研究其对运动大鼠主动脉的影响
  • 细胞CoQ摄取检测

Biochem/physiol Actions

辅酶Q10是一种内源性细胞抗氧化剂，是电子传递链的重要组成部分。辅酶Q10参与有氧细胞呼吸和ATP形式的能量产生。

General description

辅酶 Q（CoQ）又称泛醌，是一种脂溶性抗氧化剂，是线粒体电子传递链的重要组成部分。该分子含有一个生物活性醌，包含一个苯醌环和一个异戊二烯侧链。Q10在细胞质和线粒体中合成（），通过有氧细胞呼吸产生ATP。免疫系统的顺利运行和心血管健康都需要CoQ10（）。抑制炎症基因表达的能力显示了它的抗炎特性（）。 基因缺陷或衰老导致CoQ10缺乏，表现为免疫功能受到抑制。()

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000521134
0000521134
0000508531
0000508531
0000287626

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Lionel Van Maldergem et al.
Annals of neurology, 52(6), 750-754 (2002-11-26)
A 31-year-old woman had encephalopathy, growth retardation, infantilism, ataxia, deafness, lactic acidosis, and increased signals of caudate and putamen on brain magnetic resonance imaging. Muscle biochemistry showed succinate:cytochrome c oxidoreductase (complex II-III) deficiency. Both clinical and biochemical abnormalities improved remarkably
Jan Aaseth et al.
Mechanisms of ageing and development, 197, 111521-111521 (2021-06-16)
Coenzyme Q10 (CoQ10) is an essential component of the mitochondrial electron transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells produce CoQ10 by a specialized cytoplasmatic-mitochondrial pathway. CoQ10 deficiency can result from genetic failure or
Steven Lunetta et al.
Journal of AOAC International, 91(4), 702-708 (2008-08-30)
An international collaborative study was conducted of a high-performance liquid chromatographic (HPLC)-UV method for the determination of coenzyme Q10 (CoQ10, ubidecarenone) in raw materials and dietary supplements. Ten collaborating laboratories determined the total CoQ10 content in 8 blind duplicate samples.
E L Appelkvist et al.
The Clinical investigator, 71(8 Suppl), S97-102 (1993-01-01)
Inhibitors of hydroxymethylglutaryl coenzyme A reductase are used clinically to decrease blood levels of low-density lipoprotein cholesterol in hypercholesterolemic patients. However, little is known about the possible effects of these inhibitors on dolichol and cholesterol synthesis. Oral administration of mevinolin
David Mantle et al.
Antioxidants (Basel, Switzerland), 10(5) (2021-06-03)
Coenzyme Q10 (CoQ10) has a number of important roles in the cell that are required for optimal functioning of the immune system. These include its essential role as an electron carrier in the mitochondrial respiratory chain, enabling the process of
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