生物来源
Rosemarinus officinalis L.
质量水平
表单
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
运输
dry ice
储存温度
−20°C
SMILES字符串
CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O
InChI
1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
InChI key
XUSYGBPHQBWGAD-PJSUUKDQSA-N
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一般描述
卡诺醇(CAR)是一种邻二酚二萜，提取自地中海草本植物迷迭香(Rosmarinus officinalis L. )。它最初是从鼠尾草(Sage)植物中分离出来的。卡诺醇也是亲电子分子。
应用
卡诺醇已被用作一种抗癌剂：
- 测试其对肿瘤干细胞样细胞(CSC)和多形性成胶质细胞瘤 (GBM)细胞
- 的抗癌及抗增殖作用，以在人类宫颈癌模型中，检测其对不同遗传致癌途径上、下调节的19个基因以及对海拉细胞的抗癌作用
- 作为参考标准品，采用液相色谱-串联质谱(LC/ESI-MS/MS)对迷迭香提取物的代谢物进行鉴定和定量
生化/生理作用
一种具有抗氧化和抗癌活性的酚类二萜。
麝香醇和鼠尾草酸(CA)的抗氧化活性占迷迭香叶的90%。在慢性应激条件下，它具有神经保护特性，可以防止神经炎症和氧化应激诱导的脑损伤。卡诺醇是一种强效化疗药物，研究用于多种类型的癌症，如乳腺癌、白血病、皮肤癌、前列腺癌和结肠癌。它也可用作抗菌剂。
警示用语：
Warning
危险声明
预防措施声明
危险分类
Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Marcos Roberto de Oliveira
Molecular neurobiology, 53(9), 6155-6168 (2016-11-01)
Carnosic acid (CA) and carnosol are the major diterpenes found in Rosmarinus officinalis (rosemary), a culinary spice. CA and carnosol account for over 90 % of its anti-oxidant activity in rosemary leaves. The diterpenes exert anti-oxidant, anti-inflammatory, and anti-carcinogenic activities, and
The anticancer molecular mechanism of Carnosol in human cervical cancer cells: An in vitro study
Hafidha RR and Abdulamirb AS
Asia-Pacific Journal of Molecular Biology and Biotechnology, 88-98 (2020)
Seitaro Nakagawa et al.
Antibiotics (Basel, Switzerland), 9(4) (2020-04-05)
Staphylococcus aureus is an opportunistic pathogen and a common cause of skin infection. S. aureus also plays a role in the pathogenesis of the chronic inflammatory skin disease, atopic dermatitis. S. aureus virulence involves activation of the quorum sensing agr
Kyung-Soo Chun et al.
Journal of cancer prevention, 19(2), 103-110 (2014-10-23)
Cancer is an unbeaten health challenge for the humankind. After striving for decades to find a cancer cure, attention has now been shifted to reduce the morbidity and mortality from cancer by halting the course of tumor development. Numerous bioactive
Saeed Samarghandian et al.
BMC complementary and alternative medicine, 17(1), 249-249 (2017-05-06)
Oxidative stress through chronic stress destroys the brain function. There are many documents have shown that carnosol may have a therapeutic effect versus free radical induced diseases. The current research focused the protective effect of carnosol against the brain injury
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