C9630
胞苷 2′:3′-环一磷酸 单钠盐
≥95% (HPLC), synthetic, powder
别名:
2′，3′-cCMP, 2′，3′-环 CMP 单钠盐, 环胞苷酸, 胞苷 2′，3′-环磷酸酯 钠盐
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关于此项目
经验公式（希尔记法）:
C9H11N3NaO7P
化学文摘社编号:
分子量:
327.16
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
239-813-2
MDL number:
Beilstein/REAXYS Number:
4086446
Assay:
≥95% (HPLC)
Biological source:
synthetic
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
产品名称
胞苷 2′:3′-环一磷酸 单钠盐, ≥95% (HPLC)
InChI
1S/C9H12N3O7P.Na/c10-5-1-2-12(9(14)11-5)8-7-6(4(3-13)17-8)18-20(15,16)19-7;/h1-2,4,6-8,13H,3H2,(H,15,16)(H2,10,11,14);/q;+1/p-1/t4-,6-,7-,8-;/m1./s1
InChI key
SQOIXCJUYWSZDW-IAIGYFSYSA-M
SMILES string
[Na+].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@H]3OP([O-])(=O)O[C@@H]23
biological source
synthetic
assay
≥95% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
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Application
胞苷 2′，3′-环一磷酸（2′，3′-环胞苷一磷酸）（2′，3′-cCMP）被用作一种模型底物，用于各种核糖核酸酶（尤其是核糖核酸酶 A）动力学分析。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
pH-Stat titration allows the continuous determination of ribonuclease A activity toward cytidine 2',3'-cyclic monophosphate at high substrate concentrations.
Jens Köditz et al.
Analytical biochemistry, 305(2), 281-284 (2002-06-11)
M Moussaoui et al.
The Journal of biological chemistry, 273(40), 25565-25572 (1998-09-25)
The kinetics of the hydrolysis of cytidine 2',3'-cyclic phosphate (C>p) to 3'-CMP by ribonuclease A are multiphasic at high substrate concentrations. We have investigated these kinetics by determining 3'-CMP formation both spectrophotometrically and by a highly specific and quantitative chemical
S Adinolfi et al.
FEBS letters, 398(2-3), 326-332 (1996-12-02)
In the ribonuclease superfamily, dimericity is a unique feature of bovine seminal RNase (BS-RNase). In about two-thirds of native BS-RNase molecules, the two subunits interchange their N-terminal tails, thus generating domain-swapped dimers (MxM), which mostly responsible for enzyme biological activities
Mojca Bencina et al.
Journal of chromatography. A, 1144(1), 135-142 (2007-01-20)
In gene therapy and DNA vaccination, RNA removal from DNA preparations is vital and is typically achieved by the addition of ribonuclease into the sample. Removal of ribonuclease from DNA samples requires an additional purification step. An alternative is the
Isothermal titration calorimetric study of RNase-A kinetics (cCMP→ 3′-CMP) involving end-product inhibition.
Spencer SD, Raffa RB.
Pharmaceut. Res., 21, 1642-1647 (2004)
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