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C9867

CGK733

Name: CGK733
Brand: SIGMA

≥98% (HPLC), solid

别名:

2,2-Diphenyl-n-(2,2,2-trichloro-1-[3-(4-fluoro-3-nitrophenyl)thioureido]ethyl)acetamide

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关于此项目

经验公式（希尔记法）:

C₂₃H₁₈Cl₃FN₄O₃S

化学文摘社编号:

905973-89-9

分子量:

555.84

NACRES:

NA.77

PubChem Substance ID:

24724454

UNSPSC Code:

12352200

MDL number:

MFCD09038682

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c3ccccc3)C(Cl)(Cl)Cl)ccc1F

InChI

1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)

InChI key

HLCDNLNLQNYZTK-UHFFFAOYSA-N

Biochem/physiol Actions

Originally published as a selective ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) kinase inhibitor, which causes reversible reprogramming of cellular lifespan, conferred robust growth to senescent cells that had ceased proliferation.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Coronavirus infection induces DNA replication stress partly through interaction of its nonstructural protein 13 with the p125 subunit of DNA polymerase δ.

Ling Hui Xu et al.

The Journal of biological chemistry, 286(45), 39546-39559 (2011-09-16)

Perturbation of cell cycle regulation is a characteristic feature of infection by many DNA and RNA viruses, including Coronavirus infectious bronchitis virus (IBV). IBV infection was shown to induce cell cycle arrest at both S and G(2)/M phases for the

Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression.

Olga V Leontieva et al.

Aging, 3(11), 1078-1091 (2011-12-14)

In yeast, chronological senescence (CS) is defined as loss of viability in stationary culture. Although its relevance to the organismal aging remained unclear, yeast CS was one of the most fruitful models in aging research. Here we described a mammalian

Interleukin 6-triggered ataxia-telangiectasia mutated kinase activation facilitates epithelial-to-mesenchymal transition in lung cancer by upregulating vimentin expression.

Yi Na Jiang et al.

Experimental cell research, 381(2), 165-171 (2019-05-18)

Matrix metalloproteinases (MMPs) and the epithelial-mesenchymal transition (EMT) contribute to metastasis. As shown in our previous studies, interleukin-6 (IL-6) induces ATM phosphorylation to increase MMP expression and metastasis in lung cancer. However, the exact roles of ATM activation in the

CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells.

Huan Wang et al.

Biochemical and biophysical research communications, 422(1), 103-108 (2012-05-09)

Hepatocellular carcinoma (HCC) is one of the most deadly human cancers. Chronic hepatitis B virus (HBV) infection is one of the predominant risk factors associated with the development of HCC and complicates the treatment of HCC. In this study, we

The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.

John P Alao et al.

Radiation oncology (London, England), 4, 51-51 (2009-11-12)

The ataxia telangiectasia mutated (ATM) and the ATM- related (ATR) kinases play a central role in facilitating the resistance of cancer cells to genotoxic treatment regimens. The components of the ATM and ATR regulated signaling pathways thus provide attractive pharmacological

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全球贸易项目编号

货号	GTIN
C9867-5MG	04061832445335
C9867-25MG	04061832283906

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