跳转至内容
Merck
CN

主要文件

查看所有文档

C9915

ω-Conotoxin GVIA

≥97% (HPLC)

登录 查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:
C120H182N38O43S6
化学文摘社编号:
106375-28-4
分子量:
3037.35
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00076620
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

Quality Level

200

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ~70%

storage temp.

−20°C

Gene Information

human ... CACNA1B(774)
mouse ... CACNA1B(12287)
rat ... CACNA1B(257648)

Application

ω-Conotoxin GVIA has been used as an antagonist for N-type calcium channel (CaV2.2) in various studies.
Powerful probe for exploring the vertebrate pre-synaptic terminal.

Biochem/physiol Actions

ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds. It inhibits central neurotransmitter release and also exhibits antihypertensive, analgesic and neuroprotective activities.
Blocks specific voltage-dependent N-type Ca2+ channels in neurons, but not in muscle; does not bind to either the dihydropyridine or verapamil binding sites; peptide first isolated from the marine snail Conus geographus L.

Other Notes

Lyophilized from 0.1% TFA in H2O

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

高风险级别生物产品--毒素类产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000149189
059M4842V
068M4794V
076M4815V

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

相关内容

Data Sheet - C9915

Instructions

C J Herrero et al.
British journal of pharmacology, 127(6), 1375-1387 (1999-08-24)
Rat alpha3beta4 or alpha7 neuronal nicotinic acetylcholine receptors (AChRs) were expressed in Xenopus laevis oocytes, and the effects of various toxins and non-toxin Ca2+ channel blockers studied. Nicotinic AChR currents were elicited by 1 s pulses of dimethylphenylpiperazinium (DMPP, 100
Crotoxin from Crotalus durissus terrificus snake venom induces the release of glutamate from cerebrocortical synaptosomes via N and P/Q calcium channels
da Silva Lomeo R, et al.
Toxicon, 85(1), 5-16 (2014)
Angela R Wild et al.
Cell reports, 26(13), 3537-3550 (2019-03-28)
Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range signaling from synapses in dendrites to the nucleus in the cell
查看所有相关文献

全球贸易项目编号

货号GTIN
C9915-.5MG04061833420348
C9915-.1MG04061833420331