biological source
human lymph
packaging
tube of 5 μg 06070401-DNA-5UG, pkg of vial of cells 06070401-1VL
growth mode
Suspension
karyotype
46,XY.ish dup(21)(q21)(RP11-15D13++,RP11-66H5++)
morphology
Lymphoblastoid
products
Not specified
receptors
Not specified
technique(s)
cell culture | mammalian: suitable
relevant disease(s)
cancer
shipped in
dry ice
storage temp.
−196°C
Biochem/physiol Actions
Derived from a patient with early onset Alzheimer disease and cerebral amyloid angiopathy (CAA), carrying a 6.5 Mb microduplication of the APP gene locus on chromosome 21. This is an EBV-transformed lymphoblastoid cell line.
Human EBV transformed lymphocytes Alzheimer
Preparation Note
Maintain cultures between 300,000 to 900,000 cells/ml; 5% CO2; 37°C
RPMI 1640 + 2mM Glutamine + 20% Foetal Bovine Serum (FBS).
Other Notes
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This cell line is part of the European Collection of Authenticated Cell Cultures (ECACC), an international repository managed by the United Kingdom Health Security Agency (UKHSA). No licensing agreement is required when either this cell line or the DNA extracted from it are used for internal research purposes only. Any other use of these products is prohibited without the express written permission of UKHSA. Inquiries regarding authorized use of this cell line or its genomic DNA may be directed to culturecollections@ukhsa.gov.uk.