COV434

COV434 has been used to study:

• the effect of 17β-estradiol on granulosa cell tumor growth, migration and invasion
• if mutant p53 (inactivatible R248Q hotspot mutation) works as a cancer-specific drug target
• the expression of TLR (toll-like receptor) and its function in the cell line

Human ovarian granulosa tumour

Human ovarian granulosa tumour cell line established from a solid primary tumour.

DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS)

Split confluent cultures 1:2 to 1:5 i.e. seeding at 2-4x10,000 cells/cm² using trypsin/EDTA; 5% CO₂; 37°C.

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This cell line is part of the European Collection of Authenticated Cell Cultures (ECACC), an international repository managed by the United Kingdom Health Security Agency (UKHSA). No licensing agreement is required when either this cell line or the DNA extracted from it are used for internal research purposes only. Any other use of these products is prohibited without the express written permission of UKHSA. Inquiries regarding authorized use of this cell line or its genomic DNA may be directed to culturecollections@ukhsa.gov.uk.