LB443

Study of DNA repair deficiencies

Established by EBV transformation of mononuclear cell from a peripheral blood sample from a 4 year old male patient. The patient was diagnosed with trichothiodystrophy (TTD), a syndrome connected to deficiency in excision repair of ultraviolet radiation induced DNA damage. Studies with fibroblasts from the same patient, known as TTD4BR, have been published.

Human lymphoblastoid, trichothiodystrophy, EBV-transformed

Maintain cultures between 3-9 x 100,000 cells/ml, dilute every 1-2 days to 3 x 100,000 cells/ml; 5% CO₂, 37°C

RPMI 1640 + 4mM Glutamine + 200 μg/ml Sodium Pyruvate (NaPy) + 15% Heat Inactivated (HI-FBS).

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