生物来源
human urine
质量水平
无菌性
sterile-filtered
表单
lyophilized powder
分子量
37.9 kDa
包含
mannitol
包装
vial of ~5,000 IU
drug control
Home Office Schedule 4.2
杂质
HBsAg, HCV and HIV-1/HIV-2, tested negative
溶解性
water: 10 mL/vial, clear to slightly hazy, colorless
UniProt登记号
运输
ambient
储存温度
−20°C
基因信息
human ... CGA(1081)
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一般描述
由 92 个氨基酸 α 链组成的糖蛋白激素，与 LH、FSH 和 TSH 相同； 和一个独特的 149 个氨基酸 β 链。由绒毛膜组织产生，负责在妊娠早期维持黄体。也由滋养层细胞肿瘤产生，其特征是游离 hCG β-链升高和高糖基化 hCG。
Chorionic gonadotropin human (CGA or hCG) is a heterodimer and belongs to the cystine knot growth factor superfamily. It exists as six variants namely hCGn, hCGβ, hCGβn, hCGβcf and hCGα including hCG. CGA is mapped to human chromosome 6q14.3. hCG comprises of α and β chain.
应用
Chorionic gonadotropin human has been used:
- to induce oocyte maturation in cultured follicles
- along with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice
- as medium component for fetal testes culture to aid steroidogenic responsiveness
生化/生理作用
Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas.
制备说明
When reconstituted with water to a concentration of 1,000 IU/mL, the vial will also contain 0.02 M sodium phosphate buffer (pH approx. 7.2) and 20 mg/mL of mannitol.
分析说明
The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 5,000 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated.
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Comparison of the oocyte quality derived from two-dimensional follicle culture methods and developmental competence of in vitro grown and matured oocytes
Lee J, et al.
BioMed Research International, 2018 (2018)
Following the course of pre-implantation embryo patterning by non-linear microscopy
Kyvelidou C, et al.
Journal of Structural Biology, 176(3), 379-386 (2011)
Isabelle Mouche et al.
Methods in molecular biology (Clifton, N.J.), 691, 257-269 (2010-10-26)
The Frog Embryo Teratogenesis Assay Xenopus (FETAX) test is a development toxicity screening test. Due to the small amount of compound needed and the capability to study organogenesis in a short period of time (96 h), FETAX test constitutes an
Candidate epitopes for measurement of hCG and related molecules: the second ISOBM TD-7 workshop
Berger P, et al.
Tumor Biology, 34(6), 4033-4057 (2013)
Utility of commonly used commercial human chorionic gonadotropin immunoassays in the diagnosis and management of trophoblastic diseases
Cole LA
Clinical Chemistry, 47(2), 308-315 (2001)
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