usage
kit sufficient for 250 reactions
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... BACE1(23621)
Application
该试剂盒包含有效检测BACE1活性所需的全部试剂。其中包含筛选潜在BACE1抑制剂的酶。该检测基于荧光共振能量转移 (FRET) 技术，即在BACE1切割底物后观测增强的荧光信号。
Biochem/physiol Actions
作为一种跨膜蛋白酶，BACE1负责切割淀粉样前体蛋白 (APP) 的β位点来产生β淀粉样肽 (Aβ)。大脑中Aβ积累是阿尔茨海默氏症的主要病因。BACE1是抑制剂药物研发的靶点。
仅试剂盒组分
产品编号
说明
- Fluorescent Assay Buffer 50 mL
- Stop Solution 15 mL
- Substrate (MOCA-SEV-NL-DAEFR-DNP-RR) 500 μL
- Assay Standard 140 μL
- BACE1 (β−Secretase) 300 units 100 μL
存储类别
10 - Combustible liquids
法规信息
常规特殊物品
此项目有
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Piyoosh Sharma et al.
European journal of medicinal chemistry, 167, 510-524 (2019-02-21)
The multitarget-directed strategy offers an effective and promising paradigm to treat the complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were designed and synthesized as multi-functional inhibitors of acetylcholinesterase (AChE) and
Lucas J Gutiérrez et al.
Journal of biomolecular structure & dynamics, 37(1), 229-246 (2018-01-06)
We report in this work new substituted aminopyrimidine derivatives acting as inhibitors of the catalytic site of BACE1. These compounds were obtained from a molecular modeling study. The theoretical and experimental study reported here was carried out in several steps:
Vijay K Nuthakki et al.
Bioorganic chemistry, 90, 103062-103062 (2019-06-21)
Alkaloids have always been a great source of cholinesterase inhibitors. Numerous studies have shown that inhibiting acetylcholinesterase as well as butyrylcholinetserase is advantageous, and have better chances of success in preclinical/ clinical settings. With the objective to discover dual cholinesterase
Raúl Horacio Camarillo-López et al.
Molecules (Basel, Switzerland), 25(21) (2020-11-04)
Alzheimer's disease (AD) is a neurodegenerative disease with no cure nowadays; there is no treatment either to prevent or to stop its progression. In vitro studies suggested that tert-butyl-(4-hydroxy-3-((3-(2-methylpiperidin-yl)propyl)carbamoyl)phenyl) carbamate named the M4 compound can act as both β-secretase and
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