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β-分泌酶(BACE1) 活性检测试剂盒（荧光法）

Name: β-分泌酶(BACE1) 活性检测试剂盒（荧光法）
Brand: SIGMA

1 kit sufficient for 250 reactions

别名:

BACE1 活性检测试剂盒（荧光法）

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关于此项目

NACRES:

NA.84

UNSPSC Code:

12161503

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Quality Level

300

usage

kit sufficient for 250 reactions

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... BACE1(23621)

Application

该试剂盒包含有效检测BACE1活性所需的全部试剂。其中包含筛选潜在BACE1抑制剂的酶。该检测基于荧光共振能量转移 (FRET) 技术，即在BACE1切割底物后观测增强的荧光信号。

Biochem/physiol Actions

作为一种跨膜蛋白酶，BACE1负责切割淀粉样前体蛋白 (APP) 的β位点来产生β淀粉样肽 (Aβ)。大脑中Aβ积累是阿尔茨海默氏症的主要病因。BACE1是抑制剂药物研发的靶点。

仅试剂盒组分

产品编号

说明

Fluorescent Assay Buffer 50 mL

Stop Solution 15 mL

Substrate (MOCA-SEV-NL-DAEFR-DNP-RR) 500 μL

Assay Standard 140 μL

BACE1 (β−Secretase) 300 units 100 μL

存储类别

10 - Combustible liquids

wgk

WGK 3

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000438904

0000321495

0000220115

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New substituted aminopyrimidine derivatives as BACE1 inhibitors: in silico design, synthesis and biological assays.

Lucas J Gutiérrez et al.

Journal of biomolecular structure & dynamics, 37(1), 229-246 (2018-01-06)

We report in this work new substituted aminopyrimidine derivatives acting as inhibitors of the catalytic site of BACE1. These compounds were obtained from a molecular modeling study. The theoretical and experimental study reported here was carried out in several steps:

Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease.

Piyoosh Sharma et al.

European journal of medicinal chemistry, 167, 510-524 (2019-02-21)

The multitarget-directed strategy offers an effective and promising paradigm to treat the complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were designed and synthesized as multi-functional inhibitors of acetylcholinesterase (AChE) and

Chronic Administration of Scopolamine Increased GSK3βP9, Beta Secretase, Amyloid Beta, and Oxidative Stress in the Hippocampus of Wistar Rats.

Maricarmen Hernández-Rodríguez et al.

Molecular neurobiology, 57(9), 3979-3988 (2020-07-09)

The increase of amyloid beta (Aβ) release and hyperphosphorylation of Tau protein represents the main events related to Alzheimer's disease (AD). Furthermore, the sporadic type represents the most common form of AD. Therefore, the establishment of a non-transgenic animal model

Terrusnolides A-D, new butenolides with anti-inflammatory activities from an endophytic Aspergillus from Tripterygium wilfordii.

Changxing Qi et al.

Fitoterapia, 130, 134-139 (2018-08-31)

Terrusnolides A-D (1-4), four butenolides were isolated from an endophytic Aspergillus from Tripterygium wilfordii. The structures of 1-4 were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculation. It is interesting that 1 was a butenolide derived by

New small-size peptides modulators of the exosite of BACE1 obtained from a structure-based design.

Lucas J Gutierrez et al.

Journal of biomolecular structure & dynamics, 35(2), 413-426 (2016-01-28)

We report here two new small-size peptides acting as modulators of the β-site APP cleaving enzyme 1 (BACE1) exosite. Ac-YPYFDPL-NH2 and Ac-YPYDIPL-NH2 displayed a moderate but significant inhibitory effect on BACE1. These peptides were obtained from a molecular modeling study.

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货号	GTIN
CS0010-1KT	04061833553053

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