推荐产品
检测方案
≥99%
质量水平
形式
liquid
浓度
100 mM in H2O
颜色
colorless
异质活性
DNase, RNase, none detected
运输
dry ice
储存温度
−20°C
SMILES字符串
[Na].OC1CC(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N2C=CC(=O)NC2=O
InChI
1S/C9H15N2O14P3.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17);;
InChI key
FVFWWPFKJNTHIQ-UHFFFAOYSA-N
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相关类别
一般描述
2′-Deoxyuridine 5′-triphosphate (dUTP) is incorporated into DNA during DNA synthesis. It is one of the main intermediate during pyrimidine nucleotide biosynthesis. It is one of the sources of uracil in DNA. Deoxyuridine 5′-triphosphate nucleotidohydrolase suppresses the incorporation of dUTP into DNA. It converts dUTP to 2′-deoxyuridine 5′-monophosphate (dUMP).
应用
2′-Deoxyuridine 5′-triphosphate sodium salt solution has been used in the mouse genomic DNA amplification by polymerase chain reaction (PCR). It is also suitable for conjunction with uracil DNA glycosylase to prevent carryover contamination in PCR. The dUTP is substituted for dTTP in the PCR reaction.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Abundant non-canonical dUTP found in primary human macrophages drives its frequent incorporation by HIV-1 reverse transcriptase.
The Journal of Biological Chemistry, 286(28), 25047-25055 (2011)
dUTP incorporation into genomic DNA is linked to transcription in yeast.
Nature, 459(7250), 1150-1153 (2009)
DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli.
The Journal of biological chemistry, 252(10), 3286-3294 (1977-05-25)
Gene, 93(1), 125-128 (1990-09-01)
Polymerase chain reactions (PCRs) synthesize abundant amplification products. Contamination of new PCRs with trace amounts of these products, called carry-over contamination, yields false positive results. Carry-over contamination from some previous PCR can be a significant problem, due both to the
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(21), 7152-7167 (2010-05-28)
Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored. Here, we report that
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