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Merck
CN

D0184

Sigma-Aldrich

2′-脱氧尿苷 5′-三磷酸 钠盐 溶液

100 mM in H2O

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别名:
dUTP 钠盐
经验公式(希尔记法):
C9H15N2O14P3 · xNa+
CAS号:
分子量:
468.14 (free acid basis)
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.52

检测方案

≥99%

质量水平

形式

liquid

浓度

100 mM in H2O

颜色

colorless

异质活性

DNase, RNase, none detected

运输

dry ice

储存温度

−20°C

SMILES字符串

[Na].OC1CC(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N2C=CC(=O)NC2=O

InChI

1S/C9H15N2O14P3.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17);;

InChI key

FVFWWPFKJNTHIQ-UHFFFAOYSA-N

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一般描述

2′-Deoxyuridine 5′-triphosphate (dUTP) is incorporated into DNA during DNA synthesis. It is one of the main intermediate during pyrimidine nucleotide biosynthesis. It is one of the sources of uracil in DNA. Deoxyuridine 5′-triphosphate nucleotidohydrolase suppresses the incorporation of dUTP into DNA. It converts dUTP to 2′-deoxyuridine 5′-monophosphate (dUMP).

应用

2′-Deoxyuridine 5′-triphosphate sodium salt solution has been used in the mouse genomic DNA amplification by polymerase chain reaction (PCR). It is also suitable for conjunction with uracil DNA glycosylase to prevent carryover contamination in PCR. The dUTP is substituted for dTTP in the PCR reaction.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Abundant non-canonical dUTP found in primary human macrophages drives its frequent incorporation by HIV-1 reverse transcriptase.
Kennedy EM
The Journal of Biological Chemistry, 286(28), 25047-25055 (2011)
dUTP incorporation into genomic DNA is linked to transcription in yeast.
Kim N
Nature, 459(7250), 1150-1153 (2009)
DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli.
T Lindahl et al.
The Journal of biological chemistry, 252(10), 3286-3294 (1977-05-25)
M C Longo et al.
Gene, 93(1), 125-128 (1990-09-01)
Polymerase chain reactions (PCRs) synthesize abundant amplification products. Contamination of new PCRs with trace amounts of these products, called carry-over contamination, yields false positive results. Carry-over contamination from some previous PCR can be a significant problem, due both to the
Yan Jiang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(21), 7152-7167 (2010-05-28)
Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored. Here, we report that

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