D033
(+)-布他拉莫 盐酸盐
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关于此项目
经验公式（希尔记法）:
C25H31NO · HCl
化学文摘社编号:
分子量:
397.98
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
form
powder
Quality Level
optical activity
[α]27/D +222° in methanol(lit.)
storage condition
desiccated
color
white
solubility
DMSO: >10 mg/mL, clear
SMILES string
Cl[H].[H][C@@]12C[C@@](O)(CCN1C[C@@]3([H])c4ccccc4CCc5cccc2c35)C(C)(C)C
InChI
1S/C25H31NO.ClH/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25;/h4-10,21-22,27H,11-16H2,1-3H3;1H/t21-,22-,25-;/m0./s1
InChI key
QZRUMKUMFJJARD-AAJWHBHYSA-N
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
Application
(+)-布他拉莫盐酸盐已被用作多巴胺受体阻滞剂，用于：
- 大脑解剖切片
- 帕金森′病标本纹状体
- 人胚胎肾细胞(HEK293 cells)
- 小鼠纹状体组织
Biochem/physiol Actions
(+)-布他拉莫是多巴胺受体拮抗剂，同时也是一种活性对映体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Shoma Sato et al.
The Journal of physiology, 596(12), 2447-2461 (2018-04-17)
Synaptic potentiation in Drosophila is observed at cholinergic synapses between antennal lobe (AL) and mushroom body (MB) neurons in the adult brain; however, depression at the AL-MB synapses has not yet been identified. By ex vivo Ca2+ imaging in an
Miriam E Bocarsly et al.
Cell reports, 29(5), 1147-1163 (2019-10-31)
Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in mice and demonstrate
P J Pauwels et al.
British journal of pharmacology, 134(1), 88-97 (2001-08-28)
1. Antipsychotic drugs may mediate their therapeutic effects not only by preventing the binding of dopamine but also by decreasing the propensity of the dopamine receptor to assume an active R* state. Ligand-mediated activation and blockade of the recombinant human