D041
S(+)-Propylnorapomorphine hydrochloride
solid
别名:
S(+)-NPA hydrochloride, S(+)10,11-Dihydroxy-N-n-propylnoraporphine hydrochloride
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关于此项目
经验公式（希尔记法）:
C19H21NO2 · HCl
化学文摘社编号:
分子量:
331.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
MDL number:
InChI
1S/C19H21NO2.ClH/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14;/h3-7,15,21-22H,2,8-11H2,1H3;1H/t15-;/m0./s1
SMILES string
Cl.[H][C@@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1CCC)c24
InChI key
PCOQOGIDTIFQAM-RSAXXLAASA-N
form
solid
color
off-white
solubility
H2O: moderately soluble, ethanol: soluble (Solutions should be freshly prepared.)
storage temp.
2-8°C
Quality Level
General description
Dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidant. Solutions should be freshly prepared.
Biochem/physiol Actions
Limbic-selective dopamine antagonist.
Disclaimer
Store tightly sealed at 4 °C; subject to rapid oxidation. Packed under argon; reseal bottle under argon or nitrogen to maximize stability.
signalword
Warning
hcodes
Hazard Classifications
STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J L Neumeyer et al.
Journal of medicinal chemistry, 26(4), 516-521 (1983-04-01)
The enantiomers [(S)-(+) and (R)-(-)] of N-n-propylnorapomorphine (NPA) were synthesized. (R)-NPA was obtained by the acid-catalyzed rearrangement of N-n-propylnormorphine. (R)-NPA also was converted to (RS)-N-n-propylnorapomorphine dimethyl ether by dehydrogenation of the 10,11-O,O'-dimethyl ether of (R)-NPA with 10% palladium on carbon
R F Cox et al.
The Journal of pharmacology and experimental therapeutics, 247(1), 355-362 (1988-10-01)
Prompted by conflicting reports of both agonist and antagonist properties of the S-(+)-enantiomer of the potent dopamine agonist R-(-)-N-n-propylnorapomorphine (NPA), we carried out extracellular, single unit recording studies to compare the effects of both enantiomers on substantia nigra and ventral
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