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Merck
CN

D0444

DT-2 三氟乙酸盐

≥95% (HPLC), film

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关于此项目

经验公式(希尔记法):
C122H223N53O23 · xC2HF3O2
分子量:
2800.42 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
film
Quality level:
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产品名称

DT-2 三氟乙酸盐, ≥95% (HPLC), film

assay

≥95% (HPLC)

form

film

composition

Peptide content, ≥60%

color

colorless to white

solubility

H2O: 0.5 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

Quality Level

Biochem/physiol Actions

Cell permeable cGMP protein kinase (PKG) inhibitor

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Mark S Taylor et al.
Molecular pharmacology, 65(5), 1111-1119 (2004-04-23)
Cyclic GMP-dependent protein kinase (PKG) serves as an important physiological regulator of vascular reactivity and tone. However, available inhibitors of PKG have exhibited variable effects in intact tissue, hindering the elucidation of the functional role of PKG in blood vessels.
Christin Christensen et al.
Stem cells and development, 15(5), 647-654 (2006-11-16)
Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh
W R Dostmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14772-14777 (2000-12-20)
Arrays of octameric peptide libraries on cellulose paper were screened by using (32)P-autophosphorylated cGMP-dependent protein kinase Ialpha (cGPK) to identify peptide sequences with high binding affinity for cGPK. Iterative deconvolution of every amino acid position in the peptides identified the

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