D052
GBR 12909 二盐酸盐
≥98% (HPLC), dopamine transportef nhibitor, solid
别名:
1-（2-[双（4-氟苯基）甲氧基]乙基）-4-（3-苯丙基）哌嗪 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C28H32F2N2O · 2HCl
化学文摘社编号:
分子量:
523.49
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
GBR 12909 二盐酸盐, solid, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
颜色
white
溶解性
DMSO: >5 mg/mL (Solutions freshly prepared daily)
SMILES字符串
Cl.Cl.Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4
InChI
1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
InChI key
MIBSKSYCRFWIRU-UHFFFAOYSA-N
基因信息
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
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应用
GBR 12909二盐酸盐可作为多巴胺转运体(DAT)抑制剂，用于：
- 研究其对小鼠纹状体中脂多糖(LPS)诱导的促炎性细胞因子mRNA表达的影响
- 研究其对斑马鱼大脑神经递质释放的影响
- 小鼠纹状体的多巴胺摄取试验
生化/生理作用
GBR 12909可作为药物治疗可卡因上瘾。
GBR 12909是一种具有类似可卡因行为效应的高度选择性多巴胺再摄取抑制剂。
特点和优势
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Differential Reinforcing Effects of Cocaine and GBR-12909: Biochemical Evidence for Divergent Neuroadaptive Changes in the Mesolimbic Dopaminergic System
Srihari R T, et al.
The Journal of Neuroscience, 16(23), 7416 ?7427-7416 ?7427 (1996)
D Matecka et al.
Journal of medicinal chemistry, 39(24), 4704-4716 (1996-11-22)
The design, synthesis, and biological evaluation of compounds related to the dopamine (DA) uptake inhibitors: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (1) and 1-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (2) (GBR 12395 and GBR 12909, respectively), directed toward the development and identification of new ligands interacting with high potency and
Giovanni Hernandez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(32), 11032-11041 (2012-08-10)
Dopaminergic neurons contribute to intracranial self-stimulation (ICSS) and other reward-seeking behaviors, but it is not yet known where dopaminergic neurons intervene in the neural circuitry underlying reward pursuit or which psychological processes are involved. In rats working for electrical stimulation
Katherine M Serafine et al.
Pharmacology, biochemistry, and behavior, 102(2), 269-274 (2012-05-15)
Although cocaine readily induces taste aversions, little is known about the mechanisms underlying this effect. It has been suggested that its inhibitory effects at one of the monoamine transporters may be mediating this suppression. Using the cross-drug preexposure preparation, the
Dmitry M Mebel et al.
The European journal of neuroscience, 36(3), 2336-2346 (2012-06-21)
Mesolimbic dopamine (DA) signaling has been implicated in the incentive, reinforcing and motivational aspects of food intake. Insulin receptors are expressed on dopaminergic neurons of the ventral tegmental area (VTA), and insulin may act in the VTA to suppress feeding.
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