D0947
Dihydrotanshinone I
≥98% (HPLC)
别名:
Dihydrotanshinone I, (-)-Dihydrotanshinone I, 15,16-Dihydrotanshinone I
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关于此项目
经验公式（希尔记法）:
C18H14O3
化学文摘社编号:
分子量:
278.30
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
SMILES string
C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O
InChI key
HARGZZNYNSYSGJ-JTQLQIEISA-N
biological source
Salvia miltiorrhiza
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
red
solubility
ethanol: 1 mg/mL, clear, orange to red
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
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General description
DihydrotanshinoneI (DHTS) is a tanshinone derivative which is a soluble diterpene quinone pigment of danshen.
Application
Dihydrotanshinone I (DHTS) has been used:
- to study its cytocidal effects on chemosensitive ovarian cancer cells with or without platinum-based chemotherapy
- as a treatment to study its inhibitory effects on triple-negative breast cancer cells growth by modulating epithelial-mesenchymal transition (EMT) markers
- as a potential SARS-CoV-2 papain-like protease (PLpro) inhibitor
- as a human antigen R (HuR) inhibitor to study its role in Th17 cell differentiation related to autoimmune neuroinflammation
- as a reference standard to analyze Salvia miltiorrhiza Bunge extract (SME) components using high-performance liquid chromatography(HPLC)
Biochem/physiol Actions
Dihydrotanshinone Iis a potent anti-cancer agent with its cytotoxic, apoptosis, cell cycle arresteffects and inhibition of angiogenesis, and metastasis in cancer cells. Italso exerts cardiovascular and cerebrovascular protective effects. DHTS isan anti-inflammatory, anti-ischemia-reperfusion (I/R), anti-allergic,anti-Alzheimer’s disease properties. It is also effective againstdrug-resistant cancer cells.
Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
15,16-Dihydrotanshinone I, a Compound of Salvia miltiorrhiza Bunge, Induces Apoptosis through Inducing Endoplasmic Reticular Stress in Human Prostate Carcinoma Cells.
Chuang MT, Ho FM, Wu CC, Zhuang SY, Lin SY, Suk FM, Liang YC.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2011 (2011)
Daifei Wang et al.
Biopharmaceutics & drug disposition, 41(1-2), 54-63 (2020-01-17)
Salvia miltiorrhiza is one of the most commonly used traditional Chinese medicines in the treatment of cardiovascular and cerebrovascular diseases. Cryptotanshinone (CTS), tanshinone IIA (Tan IIA), dihydrotanshinone I (diTan I), and tanshinone I (Tan I) are the main active compounds
Preet Lal et al.
Nucleic acids research, 45(16), 9514-9527 (2017-09-22)
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post-transcriptionally regulates the fate of target RNAs. The natural product dihydrotanshinone-I (DHTS) prevents the association
Jing Chen et al.
Journal of immunology (Baltimore, Md. : 1950), 204(8), 2076-2087 (2020-03-15)
Dysregulated Th17 cell differentiation is associated with autoimmune diseases such as multiple sclerosis, which has no curative treatment. Understanding the molecular mechanisms of regulating Th17 cell differentiation will help find a novel therapeutic target for treating Th17 cell-mediated diseases. In
Nan Mi et al.
Journal of pharmaceutical and biomedical analysis, 164, 70-85 (2018-10-26)
Metabolites derived from traditional Chinese medicine (TCM) are becoming active substances of pharmacologically as well as promising sources for discovering new drugs. However, detection and identification of constituents in vivo remains a challenge for TCM, due to massive endogenous interference
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