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Merck
CN

D122

Sigma-Aldrich

多潘立酮

≥98% (HPLC), Dopamine D2 receptor antagonist, powder

别名:

4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine

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关于此项目

经验公式（希尔记法）:
C22H24ClN5O2
化学文摘社编号:
57808-66-9
分子量:
425.91
EC 号:
260-968-7
MDL编号:
MFCD00069256
UNSPSC代码:
12352200
PubChem化学物质编号:
24277911
NACRES:
NA.77

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产品名称

多潘立酮, powder, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white

溶解性

DMSO: >10 mg/mL
0.1 M HCl: soluble
0.1 M NaOH: slightly soluble
H2O: insoluble

创始人

Johnson & Johnson

SMILES字符串

Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1

InChI

1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)

InChI key

FGXWKSZFVQUSTL-UHFFFAOYSA-N

基因信息

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), KCNH2(3757)
rat ... Drd1a(24316), Drd2(24318), Drd3(29238), Htr3a(79246)

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相关类别

生化/生理作用

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

特点和优势

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361fd

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000276223
0000276223
0000126723
0000126723
0000121073

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Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity.
P M Laduron et al.
Biochemical pharmacology, 28(14), 2161-2165 (1979-07-15)
Luc M Hondeghem
Journal of cardiovascular pharmacology, 61(3), 218-225 (2012-11-29)
Domperidone (antinausea/vomiting agent) was recently shown by several groups to increase sudden cardiac death (SCD). Drug-induced disturbances of cardiac repolarization may be a major mechanism. Experiments were executed in isolated female rabbit hearts perfused for 150 minutes with domperidone 30
D S Pritchard et al.
British journal of clinical pharmacology, 59(6), 725-729 (2005-06-14)
To determine whether there is robust evidence of efficacy for domperidone in reducing the symptoms of gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) in children. Systematic review of randomized controlled trials (RCTs). A search was made of the Cochrane
M C Champion et al.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 135(5), 457-461 (1986-09-01)
Domperidone is a dopamine antagonist that has recently been released in Canada. Unlike metoclopramide hydrochloride, the other available dopamine antagonist, it does not readily enter the central nervous system. Domperidone acts as both an antiemetic and an upper gastrointestinal tract
Domperidone.
M C Champion
General pharmacology, 19(4), 499-505 (1988-01-01)
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