D127
右啡烷 酒石酸酯
NMDA-receptor antagonist, powder
别名:
(+)-3-羟基-N-甲基吗啡喃 (+)-酒石酸盐, 右啡烷 D-酒石酸盐
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关于此项目
经验公式（希尔记法）:
C17H23NO · C4H6O6
化学文摘社编号:
分子量:
407.46
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
产品名称
右啡烷 酒石酸酯, powder
SMILES string
O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4ccc(O)cc34
InChI
1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m10/s1
InChI key
RWTWIZDKEIWLKQ-FEBOIHDFSA-N
description
Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet
form
powder
drug control
Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet
color
white
solubility
H2O: >10 mg/mL
Quality Level
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
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Application
Dextrorphan tartrate has been used to study its effects on blood glucose levels by targeting pancreatic islets.
Biochem/physiol Actions
Dextrorphan is a noncompetitive NMDA glutamate receptor antagonist that attenuates glutamate neurotoxicity in cortical cell cultures.
A I Faden et al.
Science (New York, N.Y.), 244(4906), 798-800 (1989-05-19)
Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site. This increase in excitatory amino acids was related to the severity of the injury and was associated with
Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets
Okka S, et al.
Cell Chemical Biology (2021)
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