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D129

R-(+)-DIOA

Name: R-(+)-DIOA
Brand: SIGMA

≥98% (HPLC), potassium/chloride (K+–Cl−) co-transporter inhibitor, solid

别名:

R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₄Cl₂O₄

化学文摘社编号:

81166-47-4

分子量:

399.31

UNSPSC Code:

12352200

PubChem Substance ID:

24277830

NACRES:

NA.77

MDL number:

MFCD00069261

Assay:

≥98% (HPLC)

Form:

solid

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属性

产品名称

R-(+)-DIOA, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]27/D +18.1°, c = 0.7 in methanol(lit.)

color

white

solubility

H₂O: insoluble <0.11 mg/mL, DMSO: >20 mg/mL, 0.1 M HCl: insoluble, 0.1 M NaOH: soluble, ethanol: soluble

SMILES string

CCCC[C@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3

InChI

1S/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1

InChI key

YAWWQIFONIPBKT-FQEVSTJZSA-N

说明

Application

R-(+)-DIOA has been used as a potassium/chloride K⁺-Cl^- transport inhibitor to study its effects on:

short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
uptake of grepafloxacin by THP-1 monocytes
the uptake of moxifloxacin by THP-1 monocytes

Biochem/physiol Actions

[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K⁺–Cl⁻) co-transporter. It does not exert its effects on bumetanimide-sensitive [Na⁺,K⁺,Cl^-]-cotransport system.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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全球贸易项目编号

货号	GTIN
D129-50MG	04061832574288
D129-10MG	04061832574271