D129
R-(+)-DIOA
≥98% (HPLC), potassium/chloride (K+–Cl−) co-transporter inhibitor, solid
别名:
R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C20H24Cl2O4
化学文摘社编号:
分子量:
399.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
R-(+)-DIOA, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
optical activity
[α]27/D +18.1°, c = 0.7 in methanol(lit.)
color
white
solubility
H2O: insoluble <0.11 mg/mL, DMSO: >20 mg/mL, 0.1 M HCl: insoluble, 0.1 M NaOH: soluble, ethanol: soluble
SMILES string
CCCC[C@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3
InChI
1S/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1
InChI key
YAWWQIFONIPBKT-FQEVSTJZSA-N
Application
R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:
- short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
- uptake of grepafloxacin by THP-1 monocytes
- the uptake of moxifloxacin by THP-1 monocytes
Biochem/physiol Actions
[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl−) co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
R P Garay et al.
Naunyn-Schmiedeberg's archives of pharmacology, 334(2), 202-209 (1986-10-01)
3-Amino-5-sulfamoylbenzoic acids and several series of (aryloxy)alkanoic acids were evaluated for their inhibitory effects on two human erythrocyte ion transport systems--the Na+,K+ cotransport system and the DIDS-sensitive anion carrier. Several classic loop diuretics, including the (aryloxy)alkanoic acid-ethacrynic acid and several
Yuan-Ting Sun et al.
Glia, 58(13), 1544-1552 (2010-06-16)
Nerve conduction requires the fine tuning of ionic currents through delicate interactions between axons and Schwann cells. The K(+)-Cl(-) cotransporter (KCC) family includes four isoforms (KCC1-4) that play an important role in the maintenance of cellular osmotic homeostasis via the
Takuto Fujii et al.
European journal of pharmacology, 560(2-3), 123-126 (2007-02-17)
[(Dihydroindenyl)oxy]acetic acid (DIOA) has been used as a potent inhibitor of K+ -Cl- cotransporter (IC(50)=10 microM). Here we found that DIOA inhibited activities of P-type ATPases such as dog kidney Na+,K+-ATPase (IC(50)=53 microM), hog gastric H+,K+-ATPase (IC(50)=97 microM) and rabbit
K+-Cl- Cotransporter-3a Up-regulates Na+,K+-ATPase in Lipid Rafts of Gastric Luminal Parietal Cells.
Takuto Fujii et al.
The Journal of biological chemistry, 283(11), 6869-6877 (2008-01-08)
Gastric parietal cells migrate from the luminal to the basal region of the gland, and they gradually lose acid secretory activity. So far, distribution and function of K+-Cl(-) cotransporters (KCCs) in gastric parietal cells have not been reported. We found
L D Ochoa-de la Paz et al.
Pflugers Archiv : European journal of physiology, 449(6), 526-536 (2005-01-05)
An increase in extracellular KCl ([KCl]o) occurs under various pathological conditions in the retina, leading to retinal swelling and possible neuronal damage. The mechanisms of this KCl o-induced retinal swelling were investigated in the present study, with emphasis on the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D129-50MG | 04061832574288 |
| D129-10MG | 04061832574271 |
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持