D1414
氟哌利多
dopamine subtype 2 receptor antagonist, powder
别名:
1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone
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关于此项目
经验公式（希尔记法）:
C22H22FN3O2
化学文摘社编号:
分子量:
379.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
208-957-8
MDL number:
Form:
powder
Quality level:
产品名称
氟哌利多,
form
powder
Quality Level
originator
Johnson & Johnson
storage temp.
2-8°C
SMILES string
Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)N3C(=O)Nc4ccccc34
InChI
1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
InChI key
RMEDXOLNCUSCGS-UHFFFAOYSA-N
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), KCNH1(3756), KCNH2(3757)
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相关类别
Biochem/physiol Actions
Droperidol is a potent antagonist of dopamine subtype 2 receptor. It is an antipsychotic, which is used to treat acute behavioral anomalies. It helps to manage postoperative nausea and vomiting.
D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
A Hamik et al.
Cancer chemotherapy and pharmacology, 24(5), 307-310 (1989-01-01)
The affinities of 11 drugs for both dopamine D2 and 5-hydroxytryptamine3 (5-HT3) receptor sites were determined in brain membranes. The five "traditional" antiemetics (chlorpromazine, prochlorperazine, droperidol, fluphenazine, and domperidone) displayed high affinity (less than 20 nM) for dopamine D2 receptors
Astrid Gjelstad et al.
Analytica chimica acta, 742, 10-16 (2012-08-14)
In this paper, extraction kinetics was investigated experimentally and theoretically in hollow fiber liquid-phase microextraction (HF-LPME) and electromembrane extraction (EME) with the basic drugs droperidol, haloperidol, nortriptyline, clomipramine, and clemastine as model analytes. In HF-LPME, the analytes were extracted by
The safety and effectiveness of droperidol for sedation of acute behavioral disturbance in the emergency department
Calver L, et al.
Annals of Emergency Medicine, 66(3), 230-238 (2015)
To add or not to add? An empirical study on droperidol and intravenous patient-controlled analgesia.
Yi-Min Kuo et al.
Journal of the Chinese Medical Association : JCMA, 75(5), 227-233 (2012-05-29)
Droperidol is commonly added to intravenous patient-controlled analgesia (IVPCA) regimens as an antiemetic agent. Although some studies have demonstrated its safety and efficacy, it is not clear whether adding droperidol to IVPCA infusate without an extra loading dose can effectively
G Ormel et al.
Acta anaesthesiologica Scandinavica, 55(10), 1196-1205 (2011-11-19)
Prophylactic dexamethasone, ondansetron and droperidol have a documented effect on post-operative nausea and vomiting (PONV). Still, there is a lack of studies investigating the effect of adding dexamethasone to ondansetron and droperidol in order to treat established PONV. In this
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D1414-1G | 04061833559864 |
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