D1507
L -3,4-二羟基苯丙氨酸甲酯 盐酸盐
≥98% (HPLC), solid, L-DOPA precursor
别名:
甲基 L -多巴 盐酸盐
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关于此项目
经验公式（希尔记法）:
C10H13NO4 · HCl
化学文摘社编号:
分子量:
247.68
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
Application
L-3,4-二羟基苯丙氨酸甲酯盐酸盐用于：
- 治疗6-羟基多巴胺诱导的小鼠5-羟色胺神经元损伤
- 研究 B16F10 皮肤黑色素瘤细胞中酪氨酸酶活性
- 研究其对中脑神经元的神经保护作用
Biochem/physiol Actions
L-3,4-二羟基苯丙氨酸甲酯是 L-DOPA 的前体，可穿过血脑屏障。抗帕金森氏病药物 L-DOPA 甲酯在白血病和黑色素瘤中引发抗肿瘤功能。
Other Notes
Disclaimer
光敏性
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Intranasal administration of the dopaminergic agonists L-DOPA, amphetamine, and cocaine increases dopamine activity in the neostriatum: a microdialysis study in the rat
De Souza Silva MA, et al.
Journal of Neurochemistry, 68(1), 233-239 (1997)
Sodium tanshinone IIA silate increases melanin synthesis by activating the MAPK and PKA pathways and protects melanocytes from H2 O2-induced oxidative stress
Zhong H, et al.
Royal Society of Chemistry Advances, 9(33), 18747-18757 (2019)
Fabrizio Stocchi et al.
Movement disorders : official journal of the Movement Disorder Society, 25(12), 1881-1887 (2010-07-30)
Melevodopa hydrochloride plus carbidopa in effervescent tablets (M/C) is a readily soluble antiparkinsonian tablet formulation. A total of 221 patients with Parkinson's disease and motor fluctuations entered a randomized, double-blind, double-dummy, controlled parallel group study, which compared the effectiveness of
Xinxin Yang et al.
International journal of nanomedicine, 7, 2077-2086 (2012-05-24)
Levodopa remains the most effective drug in the treatment of Parkinson's disease. However, long-term administration of levodopa induces motor complications, such as levodopa-induced dyskinesia. The mechanisms underlying levodopa-induced dyskinesia are not fully understood. In this study, we prepared levodopa methyl
Muriel Geurts et al.
Neuroscience letters, 333(2), 146-150 (2002-11-07)
The role of dopaminergic transmission on striatal mRNA levels of regulators of G protein signalling proteins RGS 2-12 was evaluated by quantitative in situ hybridisation. A single injection of L-dopa (50 mg/kg i.p.) significantly increased the RGS2 mRNA level (by
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