D1542
1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇 盐酸盐
≥98% (TLC), Glycogen phosphorylase inhibitor, solid
别名:
2-羟甲基-3,4-吡咯烷二醇 盐酸盐
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关于此项目
经验公式（希尔记法）:
C5H11NO3 · HCl
化学文摘社编号:
分子量:
169.61
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇 盐酸盐, enzyme inhibitor
SMILES string
Cl.OC[C@H]1NC[C@@H](O)[C@@H]1O
InChI key
PZGVJCJRMKIVLJ-DEVUXVJFSA-N
InChI
1S/C5H11NO3.ClH/c7-2-3-5(9)4(8)1-6-3;/h3-9H,1-2H2;1H/t3-,4-,5-;/m1./s1
assay
≥98% (TLC)
form
solid
storage condition
under inert gas
solubility
water: 19.60-20.40 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
Gene Information
human ... PYGB(5834), PYGBL(5835), PYGL(5836), PYGM(5837)
mouse ... Gaa(14387), Glb1(12091), Treh(58866)
rat ... Man2a1(25478), Pygl(64035), Si(25588)
Biochem/physiol Actions
糖原磷酸化酶和α-葡萄糖苷酶的抑制剂。
Disclaimer
极易吸湿，在氩中储存和处理
General description
1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇是一种天然存在的吡咯烷生物碱。它存在于Arachniodes standishii 和 Angylocalyx boutiqueanus中。
Application
1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇盐酸盐已用作α-葡萄糖苷酶（GAA）抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A new resorufin-based $\alpha$-glucosidase assay for high-throughput screening
Motabar O, et al.
Analytical Biochemistry, 390(1), 79-84 (2009)
Tetrahedron Letters, 42, 5685-5685 (1986)
The synthesis from d-xylose of the potent and specific enantiomeric glucosidase inhibitors, 1, 4-dideoxy-1, 4-imino-d-arabinitol and 1, 4-dideoxy-1, 4-imin
Fleet GWJ and Smith PW
Tetrahedron, 42(20), 5685-5692 (1986)
Ze Fan et al.
Neuroscience bulletin, 36(12), 1513-1523 (2020-10-14)
General anesthesia severely affects the metabolites in the brain. Glycogen, principally stored in astrocytes and providing the short-term delivery of substrates to neurons, has been implicated as an affected molecule. However, whether glycogen plays a pivotal role in modulating anesthesia-arousal
Omid Motabar et al.
Analytical biochemistry, 390(1), 79-84 (2009-04-18)
Mutations in alpha-glucosidase cause accumulation of glycogen in lysosomes, resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have emerged as a new therapeutic
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