D1634
薯蓣皂苷元
≥93%, apoptosis inducer, powder
别名:
(25R)-5-螺甾烯-3β-醇, 3β-羟基-5-螺甾烯, 薯蓣皂素
产品名称
薯蓣皂苷元, ≥93%
方案
≥93%
表单
powder
SMILES字符串
[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]6(CC[C@@H](C)CO6)O2
InChI
1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
InChI key
WQLVFSAGQJTQCK-VKROHFNGSA-N
基因信息
human ... UGT1A4(54657)
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相关类别
一般描述
薯蓣皂苷元是一种三萜类化合物，也是薯蓣皂苷的糖基衍生物。 它存在于山药、胡芦巴（Trigonella foenum-graecum）和闭鞘姜（Costus speciosus）等植物中。
应用
薯蓣皂苷元已被用于：
- 作为分析毛瓣无患子所含总皂苷的标准品
- 口服给予大鼠，以研究其对致动脉粥样化饮食诱导的心脏、肝脏和大脑炎症介质产生的抵抗作用
- 作为标准化合物，用于检测鹰嘴豆和蒺藜的皂苷含量
生化/生理作用
薯蓣皂苷元能诱导结肠癌细胞凋亡以及诱导骨肉瘤细胞的凋亡、细胞周期停滞和环加氧酶活性。它是类固醇药物生产的前体。薯蓣皂苷元已被证明能够通过刺激胆汁排泄来促进胆固醇生成。它能够影响脂氧合酶诱导的人红白血病细胞系分化。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Fatemeh Ganjeizadeh Rohani et al.
Journal of pharmaceutical and biomedical analysis, 174, 552-560 (2019-07-01)
A novel electropolymerized molecularly imprinted polymer (MIP) film, based on diosgenin on a glassy carbon electrode (GCE), has been synthesized. Based on density functional theory (DFT), para-aminobenzoic acid (pABA), which is a green substance, was selected from five functional monomers
Andreas Blees et al.
Nature, 551(7681), 525-528 (2017-11-07)
The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum that is essential for establishing a hierarchical immune response. The PLC coordinates peptide translocation into the endoplasmic reticulum with loading and editing of major histocompatibility complex
Won Seok Yang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(6), 2434-2445 (2017-10-27)
We investigated how diosgenin, a steroidal sapogenin, has anti-tumor necrosis factor-α (TNF-α) effects in human aortic endothelial cells (HAECs). Tumor necrosis factor receptor 1 (TNFR1) was assessed by Western blot analysis. Intracellular Ca2+ was measured using Fluo-4 AM. Immunofluorescence staining
Atherogenic diet induced lipid accumulation induced NFkappaB level in heart, liver and brain of Wistar rat and diosgenin as an anti-inflammatory agent
Binesh A, et al.
Life Sciences, 196, 28-37 (2018)
Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca 2+ homeostasis
Liu MJ, et al.
Cancer Chemotherapy and Pharmacology, 55(1), 79-90 (2005)
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