D1822
多西环素 一水合物
别名:
6-Deoxy-5-oxytetracycline monohydrate, Doxycycline
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关于此项目
经验公式（希尔记法）:
C22H24N2O8 · H2O
化学文摘社编号:
分子量:
462.45
MDL编号:
UNSPSC代码:
51284030
PubChem化学物质编号:
NACRES:
NA.85
表单
powder or crystals
质量水平
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycoplasma
parasites
作用机制
protein synthesis | interferes
储存温度
−20°C
SMILES字符串
O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14
InChI
1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key
XQTWDDCIUJNLTR-CVHRZJFOSA-N
基因信息
human ... MMP1(4312), MMP13(4322), MMP7(4316), MMP8(4317)
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应用
- In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
- It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
- It has also been used as an antimicrobial agent.
生化/生理作用
Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.
其他说明
Keep container tightly closed in a dry and well-ventilated place.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
涉药品监管产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
In vitro antimicrobial susceptibility testing of bacterial enteropathogens causing traveler's diarrhea in four geographic regions.
Gomi H, et al.
Antimicrobial Agents and Chemotherapy, 45, 212-216 (2001)
Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro.
Li HT, et al.
The Biochemical Journal, 467, 507-515 (2015)
I Chopra et al.
Microbiology and molecular biology reviews : MMBR, 65(2), 232-60 (2001-05-31)
Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. They are inexpensive antibiotics, which have been used extensively in the prophlylaxis and therapy
Uninterpretable cerebrospinal fluid absorbance scan caused by doxycycline therapy.
Jan Miller
Annals of clinical biochemistry, 56(5), 619-622 (2019-06-07)
Andi Dian Permana et al.
Pharmaceutics, 11(7) (2019-07-20)
Conventional oral administration of antifilariasis drugs results in nonspecific targeting of the drugs and the intradermal delivery of nanoparticles with sizes of <100 nm could be used to improve lymphatic uptake. This study investigated the combination of nanosuspension and dissolving
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