D1822
多西环素 一水合物
别名:
6-Deoxy-5-oxytetracycline monohydrate, Doxycycline
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关于此项目
经验公式（希尔记法）:
C22H24N2O8 · H2O
化学文摘社编号:
分子量:
462.45
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51284030
MDL number:
Quality Segment
form
powder or crystals
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites
mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14
InChI
1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key
XQTWDDCIUJNLTR-CVHRZJFOSA-N
Gene Information
human ... MMP1(4312), MMP13(4322), MMP7(4316), MMP8(4317)
Application
- In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
- It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
- It has also been used as an antimicrobial agent.
Biochem/physiol Actions
Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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signalword
Warning
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2