D1822
多西环素 一水合物
别名:
6-Deoxy-5-oxytetracycline monohydrate, Doxycycline
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关于此项目
经验公式（希尔记法）:
C22H24N2O8 · H2O
化学文摘社编号:
分子量:
462.45
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51284030
MDL number:
Quality Level
InChI key
XQTWDDCIUJNLTR-CVHRZJFOSA-N
SMILES string
O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14
InChI
1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
form
powder or crystals
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mycoplasma
parasites
mode of action
protein synthesis | interferes
storage temp.
−20°C
Gene Information
human ... MMP1(4312), MMP13(4322), MMP7(4316), MMP8(4317)
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Application
- In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
- It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
- It has also been used as an antimicrobial agent.
Biochem/physiol Actions
Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
In vitro antimicrobial susceptibility testing of bacterial enteropathogens causing traveler's diarrhea in four geographic regions.
Gomi H, et al.
Antimicrobial Agents and Chemotherapy, 45, 212-216 (2001)
The IFITM proteins inhibit HIV-1 infection.
Lu J, et al.
Journal of Virology, 85, 2126-2137 (2011)
Uninterpretable cerebrospinal fluid absorbance scan caused by doxycycline therapy.
Jan Miller
Annals of clinical biochemistry, 56(5), 619-622 (2019-06-07)
I Chopra et al.
Microbiology and molecular biology reviews : MMBR, 65(2), 232-60 (2001-05-31)
Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. They are inexpensive antibiotics, which have been used extensively in the prophlylaxis and therapy
Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro.
Li HT, et al.
The Biochemical Journal, 467, 507-515 (2015)
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