D185
二亚乙基三胺/一氧化氮加合物
≥97% (NMR), solid
别名:
2,2′-(羟基亚硝基肼)双乙胺, 二乙烯三胺/一氧化氮加合物(DETA/NO)
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关于此项目
经验公式（希尔记法）:
C4H13N5O2
化学文摘社编号:
分子量:
163.18
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥97% (NMR)
表单
solid
储存条件
desiccated
under inert gas
颜色
off-white
溶解性
H2O: >20 mg/mL
运输
dry ice
储存温度
−20°C
SMILES字符串
NCCN(CC[NH3+])N([O-])N=O
InChI
1S/C4H12N5O2/c5-1-3-8(4-2-6)9(11)7-10/h1-6H2/q-1/p+1
InChI key
PAOXTYJXTPPVHU-UHFFFAOYSA-O
应用
二亚乙基三胺/一氧化氮加合物作为一氧化氮(NO)供体的应用实例：
- 评估NO对绵羊滋养外胚层(oTr1)细胞增殖的直接作用
- 试验其在无巨噬细胞的情况下是否可对MOPC315浆细胞瘤细胞系重新产生NO的生长抑制作用
- 在猪模型中关联NO诱导的房水外流功能（有对照）和外流通路管径变化
生化/生理作用
二亚乙基三胺/一氧化氮加合物(DETA/NO)是一种NONOate（R1R2N-(NO-)-N=O），生成的NO具有最长的体外半寿期。吸入型DETA/NO可用作动物和人类的肺血管扩张剂。这种NO供体在溶液中以可控方式释放一氧化氮。DETA/NO参与蛋白下调和p53表达上调。它可增强p53翻译后修饰，也可下调Nanog和Oct4 mRNA水平。
免责声明
空气敏感
警示用语：
Danger
危险声明
危险分类
Self-react. C
储存分类代码
5.2 - Organic peroxides and self-reacting hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Susannah Waxman et al.
Investigative ophthalmology & visual science, 59(12), 4886-4895 (2018-10-23)
To correlate outflow function and outflow tract vessel diameter changes induced by nitric oxide (NO). In a porcine anterior segment perfusion model, the effects of a nitric oxide donor (100 μM DETA-NO) on outflow facility were compared with controls (n
Chen Fuh Lam et al.
Clinical and experimental pharmacology & physiology, 30(9), 709-711 (2003-08-28)
1. Inhaled diethylenetriamine nitric oxide adduct (DETA/NO) has been shown to be a selective pulmonary vasodilator in animal and human studies. The aims of the present study were to investigate the effect of DETA/NO on mouse precontracted isolated tracheal smooth
Xiaoqiu Wang et al.
Biology of reproduction, 92(3), 75-75 (2015-02-06)
In mammal species, arginine is a multifunctional amino acid required for survival, growth, and development of conceptuses (embryo/fetus and associated extraembryonic membranes) during the peri-implantation period of pregnancy. However, functional roles of arginine with respect to it being a substrate
Elaine K Gregory et al.
American journal of surgery, 202(5), 536-540 (2011-09-29)
S-nitrosothiols (SNO) release nitric oxide (NO) through interaction with ascorbic acid (AA). However, little is known about their combined effect in the vasculature. The aim of this study was to investigate the effect of AA on SNO-mediated NO release, proliferation
Marcela Simontacchi et al.
Plant science : an international journal of experimental plant biology, 183, 159-166 (2011-12-27)
This work was aimed to investigate nitrosyl-Fe complexes formation by reaction of endogenous ligands and Fe, in sorghum embryonic axes exposed to NO-donors. Electron paramagnetic resonance (EPR) was employed to detect the presence of nitrosyl-Fe complexes in plant embryos, as
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