D185
二亚乙基三胺/一氧化氮加合物
≥97% (NMR), solid
别名:
2,2′-(羟基亚硝基肼)双乙胺, 二乙烯三胺/一氧化氮加合物(DETA/NO)
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关于此项目
经验公式（希尔记法）:
C4H13N5O2
化学文摘社编号:
分子量:
163.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (NMR)
Form:
solid
Storage condition:
desiccated, under inert gas
InChI
1S/C4H12N5O2/c5-1-3-8(4-2-6)9(11)7-10/h1-6H2/q-1/p+1
SMILES string
NCCN(CC[NH3+])N([O-])N=O
InChI key
PAOXTYJXTPPVHU-UHFFFAOYSA-O
assay
≥97% (NMR)
form
solid
storage condition
desiccated, under inert gas
color
off-white
solubility
H2O: >20 mg/mL
shipped in
dry ice
storage temp.
−20°C
Application
二亚乙基三胺/一氧化氮加合物作为一氧化氮(NO)供体的应用实例：
- 评估NO对绵羊滋养外胚层(oTr1)细胞增殖的直接作用
- 试验其在无巨噬细胞的情况下是否可对MOPC315浆细胞瘤细胞系重新产生NO的生长抑制作用
- 在猪模型中关联NO诱导的房水外流功能（有对照）和外流通路管径变化
Biochem/physiol Actions
二亚乙基三胺/一氧化氮加合物(DETA/NO)是一种NONOate（R1R2N-(NO-)-N=O），生成的NO具有最长的体外半寿期。吸入型DETA/NO可用作动物和人类的肺血管扩张剂。这种NO供体在溶液中以可控方式释放一氧化氮。DETA/NO参与蛋白下调和p53表达上调。它可增强p53翻译后修饰，也可下调Nanog和Oct4 mRNA水平。
Disclaimer
空气敏感
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
存储类别
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Xiaoqiu Wang et al.
Biology of reproduction, 92(3), 75-75 (2015-02-06)
In mammal species, arginine is a multifunctional amino acid required for survival, growth, and development of conceptuses (embryo/fetus and associated extraembryonic membranes) during the peri-implantation period of pregnancy. However, functional roles of arginine with respect to it being a substrate
Chen Fuh Lam et al.
Clinical and experimental pharmacology & physiology, 30(9), 709-711 (2003-08-28)
1. Inhaled diethylenetriamine nitric oxide adduct (DETA/NO) has been shown to be a selective pulmonary vasodilator in animal and human studies. The aims of the present study were to investigate the effect of DETA/NO on mouse precontracted isolated tracheal smooth
Susannah Waxman et al.
Investigative ophthalmology & visual science, 59(12), 4886-4895 (2018-10-23)
To correlate outflow function and outflow tract vessel diameter changes induced by nitric oxide (NO). In a porcine anterior segment perfusion model, the effects of a nitric oxide donor (100 μM DETA-NO) on outflow facility were compared with controls (n
S Mora-Castilla et al.
Cell death and differentiation, 17(6), 1025-1033 (2010-01-16)
Exposure of mouse embryonic stem (mES) cells to high concentrations of chemical nitric oxide (NO) donors promotes differentiation, but the mechanisms involved in this process at the gene expression level are poorly defined. In this study we report that culture
Marcela Simontacchi et al.
Plant science : an international journal of experimental plant biology, 183, 159-166 (2011-12-27)
This work was aimed to investigate nitrosyl-Fe complexes formation by reaction of endogenous ligands and Fe, in sorghum embryonic axes exposed to NO-donors. Electron paramagnetic resonance (EPR) was employed to detect the presence of nitrosyl-Fe complexes in plant embryos, as
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