biological source
algae
Quality Level
assay
≥98%
functional group
carboxylic acid
lipid type
omega FAs
shipped in
dry ice
storage temp.
−20°C
SMILES string
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O
InChI
1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
InChI key
MBMBGCFOFBJSGT-KUBAVDMBSA-N
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General description
二十二碳六烯酸（DHA）大量存在于大脑中。
二十二碳六烯酸（DHA）是一种含22个碳和6个双键的ω-3多不饱和脂肪酸，其第一个双键位于甲基末端的第3位（22：6 n-3）。 它是脂质膜和髓鞘的组分。
Application
cis-4,7,10,13,16,19-二十二碳六烯酸已用于：
- 用作杜氏改良Eagle培养基（DMEM）的组分，用于培养细胞进行二十二碳六烯酸（DHA）处理
- 研究其在分子和细胞水平上对人诱导多能干细胞（iPSC）衍生神经元的影响
- MTT[3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四氮唑]试验，研究对3种人肝细胞癌（HCC）细胞系（HepG2、Hep3B、Huh7）的细胞毒性作用
Biochem/physiol Actions
二十二碳六烯酸（DHA）参与中枢神经系统的生长和生理活动。它可以调节成人神经发生和神经可塑性。DHA在胎儿大脑发育中起重要作用。它可能表现出抗氧化和抗炎的特性。DHA在细胞膜流动性的调节中起重要作用。它在几个大脑发育过程中起着至关重要的作用，包括神经递质释放、基因表达、髓鞘形成、神经炎症和神经元分化。DHA对几种癌症都有抗癌作用。
二十二碳六烯酸（DHA）还可用作前列腺素和类二十烷酸等信号传导分子的前体。
Packaging
安瓿瓶装。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
143.6 °F - closed cup
flash_point_c
62 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
M Martínez
Neurology, 40(8), 1292-1298 (1990-08-01)
In confirmation of previous findings, patients with Zellweger's syndrome had extremely low levels of docosahexaenoic acid (22:6 omega 3) in the brain, liver, and kidneys. The other product of delta 4 desaturation, 22:5 omega 6, was also very significantly decreased
Walter J Lukiw et al.
The Journal of clinical investigation, 115(10), 2774-2783 (2005-09-10)
Deficiency in docosahexaenoic acid (DHA), a brain-essential omega-3 fatty acid, is associated with cognitive decline. Here we report that, in cytokine-stressed human neural cells, DHA attenuates amyloid-beta (Abeta) secretion, an effect accompanied by the formation of NPD1, a novel, DHA-derived
G Kargas et al.
Journal of chromatography, 526(2), 331-340 (1990-04-06)
A rapid, simple and highly sensitive reversed-phase high-performance liquid chromatographic method is described for the separation and quantitation of fatty acids in human serum using a very reactive fluorescent labeling reagent, 9-anthryldiazomethane. Quantitative esterification proceeds at room temperature without heat
Guang Yang et al.
Journal of cellular and molecular medicine, 19(10), 2413-2422 (2015-07-16)
Previous work from both our lab and others have indicated that exposure to 50 Hz magnetic fields (ELF-MF) was able to modify ion channel functions. However, very few studies have investigated the effects of MF on γ-aminobutyric acid (GABA) type
Ana M Torres-Guzman et al.
Arthritis research & therapy, 16(2), R64-R64 (2014-03-13)
Clinical and preclinical studies have shown that supplementation with ω-3 polyunsaturated fatty acids (ω-3 PUFAs) reduce joint destruction and inflammation present in rheumatoid arthritis (RA). However, the effects of individual ω-3 PUFAs on chronic arthritic pain have not been evaluated
商品
Lipid Induced Insulin Resistance
脂肪组织中的胰岛素耐受性减少了循环游离脂肪酸的摄入，并增加了脂肪酶对储存甘油三酯的水解。了解与胰岛素耐受性相关的激素、细胞因子和脂肪因子。
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D2534-1G | 04061835543861 |
| D2534-100MG | 04061835543854 |
| D2534-25MG | 04061835543878 |
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