D2926
二亚苯基碘鎓氯化物
≥98%, Nitric oxide synthetase inhibitor, powder
别名:
二苯基氯化碘盐
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关于此项目
经验公式（希尔记法）:
C12H8ClI
化学文摘社编号:
分子量:
314.55
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
二亚苯基碘鎓氯化物, ≥98%
Quality Level
assay
≥98%
form
powder
mp
278 °C
solubility
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
storage temp.
room temp
SMILES string
[Cl-].[I+]1c2ccccc2-c3ccccc13
InChI
1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
InChI key
FCFZKAVCDNTYID-UHFFFAOYSA-M
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
mouse ... Pik3r1(18708)
Application
二苯基氯化碘盐可作为NADPH氧化酶(NOX)抑制剂：
- 研究其对活性氧(ROS)浓度的影响，以及对临床恶性胸腔积液(MPE)样本来源中性粒细胞杀伤肿瘤细胞的抑制作用
- 在阿霉素(DOX)+鞭毛蛋白(Flagellin)处理细胞中作为烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶抑制剂，确认炎症变化在活性氧过量后发生
- 作为NOX抑制剂，研究其对肝细胞癌细胞(HepG2)中棕榈酸诱导成球能力的影响
Biochem/physiol Actions
一种从巨噬细胞和内皮细胞中提取的一氧化氮合成酶的有效且可逆的抑制剂。
一种从巨噬细胞和内皮细胞中提取的一氧化氮合成酶的有效且可逆的抑制剂。也抑制其他黄酮酶，如中性粒细胞NADPH氧化酶。
二亚苯基碘鎓(DPI)可影响线粒体功能。DPI可抑制帕金森病的神经元变性。对局灶性脑缺血具有神经保护作用。DPI可诱导干细胞样肿瘤细胞的化学静息(chemo-quiescence)表型，有效抑制细胞增殖。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
Marcin Zawrotniak et al.
Frontiers in cellular and infection microbiology, 7, 414-414 (2017-10-07)
Neutrophils use different mechanisms to cope with pathogens that invade the host organism. The most intriguing of these responses is a release of neutrophil extracellular traps (NETs) composed of decondensed chromatin and granular proteins with antimicrobial activity. An important potential
Lingdi Wang et al.
Nature communications, 8(1), 523-523 (2017-09-14)
The mitochondrial enriched GCN5-like 1 (GCN5L1) protein has been shown to modulate mitochondrial protein acetylation, mitochondrial content and mitochondrial retrograde signaling. Here we show that hepatic GCN5L1 ablation reduces fasting glucose levels and blunts hepatic gluconeogenesis without affecting systemic glucose
Qing-Xiang Yu et al.
Scientific reports, 7, 43096-43096 (2017-02-22)
Use of antibiotic-contaminated manure in crop production poses a severe threat to soil and plant health. However, few studies have studied the mechanism by which plant development is affected by antibiotics. Here, we used microscopy, flow cytometry, gene expression analysis
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D2926-10MG | 04061838445940 |
| D2926-50MG | 04061833562727 |