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Merck
CN

D2926

二亚苯基碘鎓氯化物

≥98%, Nitric oxide synthetase inhibitor, powder

别名:

二苯基氯化碘盐

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关于此项目

经验公式(希尔记法):
C12H8ClI
化学文摘社编号:
分子量:
314.55
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98%
Form:
powder
Quality level:
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产品名称

二亚苯基碘鎓氯化物, ≥98%

Quality Level

assay

≥98%

form

powder

mp

278 °C

solubility

DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

SMILES string

[Cl-].[I+]1c2ccccc2-c3ccccc13

InChI

1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1

InChI key

FCFZKAVCDNTYID-UHFFFAOYSA-M

Gene Information

Application

二苯基氯化碘盐可作为NADPH氧化酶(NOX)抑制剂:
  • 研究其对活性氧(ROS)浓度的影响,以及对临床恶性胸腔积液(MPE)样本来源中性粒细胞杀伤肿瘤细胞的抑制作用
  • 在阿霉素(DOX)+鞭毛蛋白(Flagellin)处理细胞中作为烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶抑制剂,确认炎症变化在活性氧过量后发生
  • 作为NOX抑制剂,研究其对肝细胞癌细胞(HepG2)中棕榈酸诱导成球能力的影响

Biochem/physiol Actions

一种从巨噬细胞和内皮细胞中提取的一氧化氮合成酶的有效且可逆的抑制剂。
一种从巨噬细胞和内皮细胞中提取的一氧化氮合成酶的有效且可逆的抑制剂。也抑制其他黄酮酶,如中性粒细胞NADPH氧化酶。
二亚苯基碘鎓(DPI)可影响线粒体功能。DPI可抑制帕金森病的神经元变性。对局灶性脑缺血具有神经保护作用。DPI可诱导干细胞样肿瘤细胞的化学静息(chemo-quiescence)表型,有效抑制细胞增殖。


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research


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Neutrophils use different mechanisms to cope with pathogens that invade the host organism. The most intriguing of these responses is a release of neutrophil extracellular traps (NETs) composed of decondensed chromatin and granular proteins with antimicrobial activity. An important potential
Lingdi Wang et al.
Nature communications, 8(1), 523-523 (2017-09-14)
The mitochondrial enriched GCN5-like 1 (GCN5L1) protein has been shown to modulate mitochondrial protein acetylation, mitochondrial content and mitochondrial retrograde signaling. Here we show that hepatic GCN5L1 ablation reduces fasting glucose levels and blunts hepatic gluconeogenesis without affecting systemic glucose
Qing-Xiang Yu et al.
Scientific reports, 7, 43096-43096 (2017-02-22)
Use of antibiotic-contaminated manure in crop production poses a severe threat to soil and plant health. However, few studies have studied the mechanism by which plant development is affected by antibiotics. Here, we used microscopy, flow cytometry, gene expression analysis



全球贸易项目编号

货号GTIN
D2926-10MG04061838445940
D2926-50MG04061833562727