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D2926

Sigma-Aldrich

二亚苯基碘鎓氯化物

≥98%

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别名:
二苯基氯化碘盐
经验公式（希尔记法）:
C12H8ClI
CAS号:
4673-26-1
分子量:
314.55
MDL编号:
MFCD00214165
PubChem化学物质编号:
24278032
NACRES:
NA.77

质量水平

300

检测方案

≥98%

形式

powder

mp

278 °C

溶解性

DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

储存温度

room temp

SMILES字符串

[Cl-].[I+]1c2ccccc2-c3ccccc13

InChI

1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1

InChI key

FCFZKAVCDNTYID-UHFFFAOYSA-M

基因信息

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)
mouse ... Pik3r1(18708)

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应用

二苯基氯化碘盐可作为NADPH氧化酶(NOX)抑制剂：
  • 研究其对活性氧(ROS)浓度的影响，以及对临床恶性胸腔积液(MPE)样本来源中性粒细胞杀伤肿瘤细胞的抑制作用
  • 在阿霉素(DOX)+鞭毛蛋白(Flagellin)处理细胞中作为烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶抑制剂，确认炎症变化在活性氧过量后发生
  • 作为NOX抑制剂，研究其对肝细胞癌细胞(HepG2)中棕榈酸诱导成球能力的影响

生化/生理作用

一种从巨噬细胞和内皮细胞中提取的一氧化氮合成酶的有效且可逆的抑制剂。也抑制其他黄酮酶，如中性粒细胞NADPH氧化酶。
二亚苯基碘鎓(DPI)可影响线粒体功能。DPI可抑制帕金森病的神经元变性。对局灶性脑缺血具有神经保护作用。DPI可诱导干细胞样肿瘤细胞的化学静息(chemo-quiescence)表型，有效抑制细胞增殖。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How should Product No. D2926, Diphenyleneiodonium chloride be dissolved?

    Product D2926 is soluble in DMSO at a concentration of 10 mg/mL, with strong heating. It is also easily soluble at 2.4 mg/mL in DMSO, in 0.1N NaOH (at 0.5 mg/mL), in 0.1N HCl (at 0.2 mg/mL), in ethanol (at 0.2 mg/mL) or in water (0.2 mg/mL). Stock solutions can be prepared at 10 mM in DMSO, according to O'Donnell, V. B., et al., Studies on the Inhibitory Mechanism of Iodonium Compounds with Special Reference to Neutrophil NADPH Oxidase. Biochem. J., 290(pt 1), 41-49 (1993), or at 3 x 10-8 to 3 x 10-6 M in a 5% glucose solution according to Wang, Y. X., et al., Inhibitory Actions of Diphenyleneiodonium on Endothelium-dependent Vasodilatations In Vitro and In Vivo. Br. J.Pharmacol., 110(3), 1232-1238 (1993).

  6. What is the solution stability of Product No. D2926, Diphenyleneiodonium chloride?

    A stock solution of D2926 in DMSO can be stored at -20°C for up to 3 months.

  7. Product No. D2926 is an inhibitor of nitric oxide synthase (NOS). Does Sigma-Aldrich offer any other NOS inhibitors?

    We do offer other inhibitors of NOS, such as Product Nos. M7033 (NG-Methyl-L-arginine) and A7009 (Aminoguanidine).

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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