生物来源
human placenta
质量水平
等级
Molecular Biology
表单
buffered aqueous solution
运输
dry ice
储存温度
−20°C
SMILES字符串
[P](=O)(OC2C(OC(C2)N)CO[P](=O)(OC3C(OC(C3)N)CO)O)(OCC1OC(CC1O)N)O
InChI
1S/C15H31N3O13P2/c16-13-1-7(20)11(28-13)5-25-32(21,22)31-9-3-15(18)29-12(9)6-26-33(23,24)30-8-2-14(17)27-10(8)4-19/h7-15,19-20H,1-6,16-18H2,(H,21,22)(H,23,24)
InChI key
AWBASQCACWFTGD-UHFFFAOYSA-N
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一般描述
人胎盘DNA是从单一女性供体胎盘中分离得到的，但会含有一些母体DNA。已经使用DNA探针杂交确定了性别。
应用
来自人胎盘的脱氧核糖核苷酸已用于：
- 比较DNA定量方法的效率
- 在来自膀胱癌细胞系DNA样品的实时定量PCR分析中作为标准品
- 作为内参预测游离DNA的片段化程度
- 用于限制性消化分析以鉴定人染色体22q11的低拷贝重复区域
- 比较不同人类和灵长目动物的70-bp P5外显子序列
- 计算相对于正常人组织基因的拷贝数
- 用于PCR反应
用于Southern杂交。
其他说明
DNA溶液已在4℃，pH 7.5 - 8.0，含1mM EDTA且不含抑菌剂的10 mM Tris中成功保存数月。在低浓度（约25 μg/ml）条件下，DNA倾向于吸附在塑料管表面上。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Heather Hoover et al.
Journal of proteome research, 14(9), 3670-3679 (2015-07-08)
Tumor types can be defined cytologically by their regions of chromosomal amplification, which often results in the high expression of both mRNA and proteins of certain genes contained within the amplicon. An important strategy for defining therapeutically relevant targets in
Claire E L Smith et al.
PloS one, 12(9), e0185678-e0185678 (2017-09-29)
The imprinted gene PLAGL1 is an important regulator of apoptosis and cell cycle arrest. Loss of its expression has been implicated in tumorigenesis in a range of different cancers, and overexpression during fetal development causes transient neonatal diabetes mellitus (TNDM).
Alain R Thierry et al.
Nucleic acids research, 38(18), 6159-6175 (2010-05-25)
Although circulating DNA (ctDNA) could be an attractive tool for early cancer detection, diagnosis, prognosis, monitoring or prediction of response to therapies, knowledge on its origin, form and rate of release is poor and often contradictory. Here, we describe an
Joanne S Aveyard et al.
The Journal of molecular diagnostics : JMD, 6(4), 356-365 (2004-10-28)
Many tumors have large homozygous deletions of the CDKN2A locus (encoding p14(ARF) and p16) and of CDKN2B (p15). Our aim was to determine which gene is the major target in bladder cancer. We used quantitative real-time PCR (RTQ-PCR) to determine
Naoe Kotomura et al.
PloS one, 10(5), e0128282-e0128282 (2015-05-29)
The human CYP19 gene encodes aromatase, which converts androgens to estrogens. CYP19 mRNA variants are transcribed mainly from three promoters. Quantitative RT-PCR was used to measure the relative amounts of each of the three transcripts and determine the on/off state
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