D3072
盐酸多西环素，现成溶液
100 mg/mL in DMSO, ≥95.0% (HPLC)
别名:
α-6-脱氧-5-羟基四环素盐酸盐, 2-并四苯甲酰胺, 4-（二甲氨基）- 1,4,4a,5,5a,6,11,12a-八氢-3,5,10,12,12a-五羟基-6-甲基-1,11-二氧-，盐酸盐（1:1），（4S,4aR,5S,5aR,6R,12aS）-, Doxylin, Idocyklin, 盐酸多西环素, 盐酸强力霉素
生物来源
synthetic
质量水平
无菌性
0.22 μm filtered
方案
≥95.0% (HPLC)
表单
liquid
浓度
100 mg/mL in DMSO
溶解性
DMSO: 100 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycoplasma
parasites
作用机制
protein synthesis | interferes
储存温度
−20°C
InChI
1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key
VLUQVUWDECWBTL-UQVCFKGQSA-N
相关类别
一般描述
强力霉素是一种四环素类抗生素，通常用于治疗各种感染。它是一种广谱抗生素和抑菌剂。强力霉素具有抗原生动物特性，是体内MMPs（基质金属蛋白酶）的有效抑制剂。
应用
<ul>
<li><strong>AAPS PharmSciTech: </strong>制备了结合盐酸多西环素的VA/PCL/CS基纳米纤维膜，该膜用于引导组织再生术和牙周炎治疗中的受控递送，在大鼠体内对该膜进行了评估，（Mirzaeei et al., 2024）。</li>
<li><strong>European Journal of Pharmacology: </strong>盐酸多西环素通过PI3K-Akt信号通路靶向MMP17和MMP1，从而抑制肾脏恶性横纹肌样瘤的进展（Mi et al., 2024）。</li>
</ul>
<li><strong>AAPS PharmSciTech: </strong>制备了结合盐酸多西环素的VA/PCL/CS基纳米纤维膜，该膜用于引导组织再生术和牙周炎治疗中的受控递送，在大鼠体内对该膜进行了评估，（Mirzaeei et al., 2024）。</li>
<li><strong>European Journal of Pharmacology: </strong>盐酸多西环素通过PI3K-Akt信号通路靶向MMP17和MMP1，从而抑制肾脏恶性横纹肌样瘤的进展（Mi et al., 2024）。</li>
</ul>
其他说明
保持容器密闭，并置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Megan E Forrest et al.
PloS one, 15(2), e0228730-e0228730 (2020-02-14)
Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels in the cell and is a major control point for modulating gene expression. In yeast and other model organisms, codon identity is a powerful determinant of transcript stability
Youcai Tang et al.
PloS one, 13(8), e0200897-e0200897 (2018-08-02)
Alpha-1 Antitrypsin (α1AT) Deficiency is a genetic disease in which accumulation of α1AT mutant Z (α1ATZ) protein in the ER of hepatocytes causes chronic liver injury, liver fibrosis, and hepatocellular carcinoma. No effective medical therapy is currently available for the
Adam W Whisnant et al.
Nature communications, 11(1), 2038-2038 (2020-04-29)
The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data.
Benedetta Assetta et al.
Journal of visualized experiments : JoVE, (165) (2020-11-24)
In Alzheimer's disease (AD) and other neurodegenerative disorders, oligodendroglial failure is a common early pathological feature, but how it contributes to disease development and progression, particularly in the gray matter of the brain, remains largely unknown. The dysfunction of oligodendrocyte
Olof Torper et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 7038-7043 (2013-03-27)
Cellular reprogramming is a new and rapidly emerging field in which somatic cells can be turned into pluripotent stem cells or other somatic cell types simply by the expression of specific combinations of genes. By viral expression of neural fate
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