D3072
盐酸多西环素，现成溶液
100 mg/mL in DMSO, ≥95.0% (HPLC)
别名:
α-6-脱氧-5-羟基四环素盐酸盐, 2-并四苯甲酰胺, 4-（二甲氨基）- 1,4,4a,5,5a,6,11,12a-八氢-3,5,10,12,12a-五羟基-6-甲基-1,11-二氧-，盐酸盐（1:1），（4S,4aR,5S,5aR,6R,12aS）-, Doxylin, Idocyklin, 盐酸多西环素, 盐酸强力霉素
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关于此项目
经验公式（希尔记法）:
C22H24N2O8 · HCl
化学文摘社编号:
分子量:
480.90
MDL编号:
UNSPSC代码:
51284028
NACRES:
NA.85
生物来源
synthetic
质量水平
无菌性
0.22 μm filtered
方案
≥95.0% (HPLC)
表单
liquid
浓度
100 mg/mL in DMSO
溶解性
DMSO: 100 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycoplasma
parasites
作用机制
protein synthesis | interferes
储存温度
−20°C
InChI
1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key
VLUQVUWDECWBTL-UQVCFKGQSA-N
一般描述
强力霉素是一种四环素类抗生素，通常用于治疗各种感染。它是一种广谱抗生素和抑菌剂。强力霉素具有抗原生动物特性，是体内MMPs（基质金属蛋白酶）的有效抑制剂。
应用
<ul>
<li><strong>AAPS PharmSciTech: </strong>制备了结合盐酸多西环素的VA/PCL/CS基纳米纤维膜，该膜用于引导组织再生术和牙周炎治疗中的受控递送，在大鼠体内对该膜进行了评估，（Mirzaeei et al., 2024）。</li>
<li><strong>European Journal of Pharmacology: </strong>盐酸多西环素通过PI3K-Akt信号通路靶向MMP17和MMP1，从而抑制肾脏恶性横纹肌样瘤的进展（Mi et al., 2024）。</li>
</ul>
<li><strong>AAPS PharmSciTech: </strong>制备了结合盐酸多西环素的VA/PCL/CS基纳米纤维膜，该膜用于引导组织再生术和牙周炎治疗中的受控递送，在大鼠体内对该膜进行了评估，（Mirzaeei et al., 2024）。</li>
<li><strong>European Journal of Pharmacology: </strong>盐酸多西环素通过PI3K-Akt信号通路靶向MMP17和MMP1，从而抑制肾脏恶性横纹肌样瘤的进展（Mi et al., 2024）。</li>
</ul>
其他说明
保持容器密闭，并置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
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