D3514
4,4′-二异硫氰酸十八烯-2,2′-二磺酸 二钠盐 水合物
≥80% (elemental analysis), powder
别名:
DIDS, 二钠4,4 & # 8242;-二异硫氰酸芪-2,2 & # 8242;-二磺酸酯
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关于此项目
经验公式（希尔记法）:
C16H8N2Na2O6S4 · xH2O
化学文摘社编号:
分子量:
498.48 (anhydrous basis)
UNSPSC Code:
12352200
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
8179433
Assay:
≥80% (elemental analysis)
Form:
powder
Solubility:
0.1 M potassium bicarbonate: 50 mg/mL
assay
≥80% (elemental analysis)
form
powder
reaction suitability
reagent type: cross-linking reagent
color
yellow
solubility
0.1 M potassium bicarbonate: 50 mg/mL
storage temp.
2-8°C
SMILES string
[Na+].[Na+].[O-]S(=O)(=O)c1cc(ccc1\C=C\c2ccc(cc2S([O-])(=O)=O)N=C=S)N=C=S
InChI
1S/C16H10N2O6S4.2Na/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24;;/h1-8H,(H,19,20,21)(H,22,23,24);;/q;2*+1/p-2/b2-1+;;
InChI key
GEPAYBXVXXBSKP-SEPHDYHBSA-L
Application
一种带负电荷的同双功能交联剂。异硫氰酸酯基团在pH 9.0-10.0下与伯胺反应。
使用4,4′-二异硫氰基二苯乙烯-2,2′-二磺酸二钠盐水合物：
- 兔带3蛋白抑制剂(19)
- 抑制大脑切片组织(20)中碳酸氢盐转运体
- 作为胚胎(21)中HCO3-/Cl-交换剂（阴离子交换剂）
Biochem/physiol Actions
4,4′-二异硫氰基二苯乙烯-2,2′-二磺酸是一种含异硫氰酸酯残基的阴离子烷化剂。它是一种带负电荷的同双功能交联试剂。4,4′-二异硫氰基二苯乙烯-2,2′-二磺酸是一种用于细胞转运研究的细胞阴离子渗透性特异性抑制剂。异硫氰酸酯基团在pH 9.0-10.0下与伯胺反应。4,4′-二异硫氰基二苯乙烯-2,2′-二磺酸烷基化赖氨酸残基，并通过基于靶向膜的负离子转运体间接抑制细胞凋亡。此外，还能抑制钙在小囊泡中的转运。
一种用于细胞转运研究的细胞阴离子渗透性特异性抑制剂。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
相关内容
Product Information Sheet
Egor Turovsky et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(42), 10750-10758 (2016-11-01)
Ventral regions of the medulla oblongata of the brainstem are populated by astrocytes sensitive to physiological changes in PCO2/[H+]. These astrocytes respond to decreases in pH with elevations in intracellular Ca2+ and facilitated exocytosis of ATP-containing vesicles. Released ATP propagates
Nuclease activity of the MutS homologue MutS2 from Thermus thermophilus is confined to the Smr domain
Fukui K, et al.
Nucleic Acids Research, 35(3), 850-860 (2007)
Narongrit Thongon et al.
Pflugers Archiv : European journal of physiology, 468(11-12), 1809-1821 (2016-11-21)
Hypomagnesemia is the most concerned side effect of proton pump inhibitors (PPIs) in chronic users. However, the mechanism of PPIs-induced systemic Mg2+ deficit is currently unclear. The present study aimed to elucidate the direct effect of short-term and long-term PPIs
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D3514-250MG | 04061833563267 |
| D3514-100MG | 04061833563243 |
| D3514-1G | 04061833563250 |
| D3514-25MG | 04061833563274 |