D3695
DMOG
≥98% (HPLC), powder, HIF-hydroxylase inhibitor
别名:
N-（甲氧氧乙烯）-甘氨酸甲酯, 二甲基草酰甘氨酸
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关于此项目
经验公式（希尔记法）:
C6H9NO5
化学文摘社编号:
分子量:
175.14
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
DMOG, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
H2O: >30 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
COC(=O)CNC(=O)C(=O)OC
InChI
1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
InChI key
BNJOZDZCRHCODO-UHFFFAOYSA-N
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Application
DMOG用于：
- 缺氧诱导因子（HIF）活性测定
- 研究其对HIF-1α降解和肾脏再生的影响
- 脂肪组织DMOG预处理
- CD34+细胞原代液体培养的媒介对照
- 刺激内皮细胞
二甲基草酰甘氨酸（DMOG）用作TET3蛋白抑制剂。
Biochem/physiol Actions
DMGO是一种细胞渗透脯氨酸-4-羟化酶抑制剂，上调HIF（缺氧诱导因子）。
DMGO是一种细胞渗透脯氨酸-4-羟化酶抑制剂，上调HIF（缺氧诱导因子）。HIF蛋白质水平-1α 后转录亚基被脯氨酰和天冬酰胺羟化酶调节（PAH）。PAH活性抑制增强了内源性HIF-1α水平。DMGO是一种细胞透过性、含蛋白脯氨酰羟化酶结构域的竞争性抑制剂（PHDs和HIF-PHs）。已经发现DMOG通过葡萄糖代谢保存对于NFG缺乏细胞培养有神经元保护效果。DMOG在兔子缺血再灌注模型中也可以减轻心肌损伤。DMOG比以前的抑制剂4-苯基-吡啶-2,5-二羧酸更有效（R395889；Sigma-Aldrich稀有化学文库）。IC50 is 5.18 μM.
Features and Benefits
该化合物是基因调控研究的特色产品。点击此处以了解更多的基因调控特色产品。可访问sigma.com/discover-bsm了解更多关于用于其他研究领域生物活性小分子。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jianping Peng et al.
PloS one, 12(5), e0178147-e0178147 (2017-05-26)
Acute kidney injury (AKI) leads to a worse prognosis in diabetic patients compared with prognoses in non-diabetic patients, but whether and how diabetes affects kidney repair after AKI remains unknown. Here, we used scratch-wound healing and transwell migration models to
L Gómez-Maldonado et al.
Oncogene, 34(20), 2609-2620 (2014-07-16)
The presence of hypoxic regions in solid tumors is an adverse prognostic factor for patient outcome. Here, we show that hypoxia induces the expression of Ephrin-A3 through a novel hypoxia-inducible factor (HIF)-mediated mechanism. In response to hypoxia, the coding EFNA3
Metabolic reprogramming by HIF-1 activation enhances survivability of human adipose-derived stem cells in ischaemic microenvironments
Chen C, et al.
Cell Proliferation, 50(5), e12363-e12363 (2017)
Adipogenesis, lipogenesis and lipolysis is stimulated by mild but not severe hypoxia in 3T3-L1 cells
Weiszenstein M, et al.
Biochemical and biophysical research communications, 478(2), 727-732 (2016)
Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion
Jackson CS, et al.
Stem Cell Research, 21, 124-131 (2017)
商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D3695-50MG | 04061833563526 |
| D3695-10MG | 04061833563519 |
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