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经验公式(希尔记法):
C30H40Cl2N4 · xH2O
化学文摘社编号:
分子量:
527.57 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
208-330-9
MDL number:
InChI key
CZCJAGQJOXJBST-UHFFFAOYSA-N
InChI
1S/C30H38N4.2ClH.H2O/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34;;;/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3;2*1H;1H2
SMILES string
O.[Cl-].[Cl-].Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34
assay
≥95% (titration)
form
powder
mp
≥300 °C (lit.)
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Biochem/physiol Actions
氯异喹铵是蜂毒明肽-敏感型K+通道的一种选择性阻断剂和XIAP(凋亡蛋白的X连锁抑制剂)抑制剂。它已被证明可通过线粒体功能紊乱、氧化应激以及Raf/MEK/ERK和PI3K/Akt信号通路的下调来诱导人急性早幼粒细胞白血病NB4细胞的细胞毒性。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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