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Merck
CN

D3943

DAPH

≥98% (HPLC), solid

别名:

4,5-Dianilinophthalimide, 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione, CGP 52411

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关于此项目

经验公式(希尔记法):
C20H15N3O2
化学文摘社编号:
分子量:
329.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
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产品名称

DAPH, ≥98% (HPLC), solid

InChI key

AAALVYBICLMAMA-UHFFFAOYSA-N

SMILES string

O=C1NC(=O)c2cc(Nc3ccccc3)c(Nc4ccccc4)cc12

InChI

1S/C20H15N3O2/c24-19-15-11-17(21-13-7-3-1-4-8-13)18(12-16(15)20(25)23-19)22-14-9-5-2-6-10-14/h1-12,21-22H,(H,23,24,25)

assay

≥98% (HPLC)

form

solid

color

orange

solubility

DMSO: >20 mg/mL
H2O: insoluble

storage temp.

2-8°C

Quality Level

Gene Information

human ... EGFR(1956)

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Biochem/physiol Actions

DAPH is an inhibitor of Aβ fibril formation; Protein tyrosine kinase inhibitor, specific for EGFR.

Features and Benefits

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Barbara J Blanchard et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(40), 14326-14332 (2004-09-25)
The Abeta1-42 peptide that is overproduced in Alzheimer's disease (AD) from a large precursor protein has a normal amino acid sequence but, when liberated, misfolds at neutral pH to form "protofibrils" and fibrils that are rich in beta-sheets. We find
M Slevin et al.
Journal of cellular and molecular medicine, 9(1), 85-102 (2005-03-24)
Current understanding of the patho-physiological events that follow acute ischaemic stroke suggests that treatment regimens could be improved by manipulation of gene transcription and protein activation, especially in the penumbra region adjacent to the infarct. An immediate reduction in excitotoxicity
Wei Zhang et al.
International immunopharmacology, 72, 195-203 (2019-04-17)
The bacterial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) is a potentially fatal disease, featured with extensive infection, inflammation, and airway dysfunction. With the increasing emerging of drug-resistant strains, new therapeutic strategies beyond canonical antibiotic treatment are pressingly needed. Daphnetin
Marco Breinig et al.
Molecular systems biology, 11(12), 846-846 (2015-12-25)
Small molecules often affect multiple targets, elicit off-target effects, and induce genotype-specific responses. Chemical genetics, the mapping of the genotype dependence of a small molecule's effects across a broad spectrum of phenotypes can identify novel mechanisms of action. It can
Mohamed R Mohamed et al.
Environmental toxicology and pharmacology, 38(2), 531-541 (2014-08-30)
Among various phytochemicals, coumarins comprise a very large class of plant phenolic compounds that have good nutritive value, in addition to their antioxidant effects. The purpose of the present study was to investigate the protective effects of two coumarin derivatives

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