D4008
丹酰尸胺
≥97% (TLC)
别名:
N-（5-氨基戊基）-5-二甲基氨基萘-1-磺酰胺, N-（二甲基氨基萘磺酰）-1，5-戊二胺, 丹酰尸胺
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关于此项目
经验公式（希尔记法）:
C17H25N3O2S
化学文摘社编号:
分子量:
335.46
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
EC Number:
233-326-9
Beilstein/REAXYS Number:
2951070
MDL number:
InChI key
MLEBFEHOJICQQS-UHFFFAOYSA-N
InChI
1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
SMILES string
CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
assay
≥97% (TLC)
form
powder
storage temp.
−20°C
Quality Level
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General description
丹磺酰戊二胺，也称为单丹磺酰戊二胺（MDC），是一种亲溶酶体剂。存在于酸性和富含脂质的区域。丹磺酰戊二胺还可用作溶剂极性探针。预处理后，可以抑制囊泡转运并减少轮状病毒在L细胞中的存在。
Application
据报道，丹磺酰戊二胺在甲醇中的λex为335 nm，λem为 512 nm。这一产品用于：
- 用作胞吞作用抑制剂，用于人肾近端小管HK-2细胞（62）、小鼠J774A.1巨噬细胞和人A549上皮细胞（63）
- 标记心肌细胞中的自噬泡，用于荧光显微镜研究(64)
- 用于强直性脊柱炎（AS）样品中成纤维细胞的单丹磺酰戊二胺（MDC）染色（65）
Biochem/physiol Actions
自发荧光染料丹酰尸胺或单丹磺酰尸胺（MDC）通常用于监测自噬。 由于离子捕获和与膜脂质的特异性相互作用的组合，单丹磺酰尸胺优先在自噬泡中积累。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
空气敏感，在惰性气体下处理
Other Notes
在甲醇（10 mg/mL）中测试丹酰尸胺的溶解度。据报道，丹酰尸胺可溶于 DMSO 和乙酸。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Dansylcadaverine and cytochalasin D enhance rotavirus infection of murine L cells
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Melissa S Hillwig et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(3), 1093-1098 (2011-01-05)
RNase T2 enzymes are conserved in most eukaryotic genomes, and expression patterns and phylogenetic analyses suggest that they may carry out an important housekeeping role. However, the nature of this role has been elusive. Here we show that RNS2, an
Raúl A Almeida et al.
Veterinary research communications, 35(2), 89-101 (2011-01-06)
Research on mastitis in dairy cows caused by Escherichia coli has reported the emergence of strains capable of inducing chronic mastitis and that these strains adhered to and internalized into bovine mammary epithelial cells better than strains of E. coli
Shih T Khew et al.
Biomaterials, 31(16), 4600-4608 (2010-03-13)
Transglutaminase (TGase)-modified proteins are commonly observed in a wide range of biological systems. Therefore, the identification of TGase substrates and respective consensus sites may contribute to a better understanding of the physiological role of TGase. In this study, we identified
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