D4010
2′-脱氧鸟苷5′-三磷酸 钠盐 水合物
≥96% (HPLC), synthetic (organic), powder
别名:
2′-脱氧-, 5′-三磷酸钠盐, 鸟苷, dGTP 钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C10H16N5O13P3 · xNa+ · yH2O
化学文摘社编号:
分子量:
507.18 (anhydrous free acid basis)
MDL number:
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
Assay:
≥96% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Storage temp.:
−20°C
Application
2′-脱氧鸟苷5′-三磷酸钠盐水合物已用于：
- 用作聚合酶链式反应 (PCR) 混合物中的一种成分，使用AM-毒素引物形成 PCR 产物
- 用作内标，提高毛细管电泳 (CE) 分析的分析性能，评估纯化工艺
- 用作体外酶活性测定中的推定底物，与Nudix水解酶 15 (NUDT15) 蛋白一起孵育，评估推定的 NUDT15 抑制剂
Biochem/physiol Actions
脱氧鸟苷5′-三磷酸(dGTP),一种嘌呤脱氧核糖核苷酸，是DNA聚合酶和逆转录酶的底物。 dGTP可用于研究各种核苷三磷酸酶(NTPase)和核糖核苷酸还原酶的分布、特异性和动力学。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
Yogesh A Karpe et al.
PloS one, 6(7), e22336-e22336 (2011-08-04)
Chikungunya virus (CHIKV) is an insect borne virus (genus: Alphavirus) which causes acute febrile illness in humans followed by a prolonged arthralgic disease that affects the joints of the extremities. Re-emergence of the virus in the form of outbreaks in
Si Min Zhang et al.
Cell chemical biology, 28(12), 1693-1702 (2021-07-01)
Ganciclovir (GCV) is the first-line therapy against human cytomegalovirus (HCMV), a widespread infection that is particularly dangerous for immunodeficient individuals. Closely resembling deoxyguanosine triphosphate, the tri-phosphorylated metabolite of GCV (GCV-TP) is preferentially incorporated by the viral DNA polymerase, thereby terminating
Rajesh Kasiviswanathan et al.
The Journal of biological chemistry, 286(36), 31490-31500 (2011-07-23)
During DNA synthesis, DNA polymerases must select against ribonucleotides, present at much higher levels compared with deoxyribonucleotides. Most DNA polymerases are equipped to exclude ribonucleotides from their active site through a bulky side chain residue that can sterically block the
Inchul Yang et al.
Analytical biochemistry, 335(1), 150-161 (2004-11-03)
A novel approach for quantitation of DNA (oligonucleotides) with an unprecedented accuracy of approximately 1% is reported. Quantitation of DNA is commonly performed by measuring UV absorption or fluorescence from dyes intercalated into DNA. Both methods need accurate quantitation standards
D O Zharkov et al.
The Journal of biological chemistry, 275(37), 28607-28617 (2000-07-08)
Genomic DNA is prone to oxidation by reactive oxygen species. A major product of DNA oxidation is the miscoding base 8-oxoguanine (8-oxoG). The mutagenic effects of 8-oxoG in mammalian cells are prevented by a DNA repair system consisting of 8-oxoguanine-DNA
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D4010-10MG | 04061833006856 |
| D4010-100MG | 04061833563847 |
| D4010-1G | 04061826690550 |
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