D4268
NG,NG-二甲基精氨酸 二盐酸盐
≥98% (TLC), powder, NOS inhibitor
别名:
不对称-二甲基精氨酸, ADMA
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关于此项目
经验公式（希尔记法）:
C8H18N4O2 · 2HCl
化学文摘社编号:
分子量:
275.18
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
NG,NG-二甲基精氨酸 二盐酸盐,
SMILES string
Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O
InChI
1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
InChI key
SYLNVYJOPZWPJI-ILKKLZGPSA-N
assay
≥98% (TLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
room temp
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
Application
NG,NG-二甲基精氨酸二盐酸盐曾被用于：
- 研究其对大鼠头端延髓腹外侧区(RVLM) 心血管活动的影响
- ，作为测量L-精氨酸和二甲基精氨酸的标准
- 来研究其对肝脏恶化的影响
Biochem/physiol Actions
体内和体外可逆的一氧化氮合成酶抑制剂。
General description
N G 、 N G -二甲基精氨酸二盐酸盐是一种甲基化精氨酸衍生物，由肝脏产生。与肝硬化、酒精性肝炎和急性肝衰竭 (ALF) 有关。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine
Okuyucu A, et al.
Turkish Journal of Biology, 40(2), 452-461 (2016)
Jasmohan S Bajaj et al.
Gastroenterology, 159(5), 1715-1730 (2020-07-21)
Inpatients with cirrhosis have high rates of acute-on-chronic failure (ACLF) development and high mortality within 30 days of admission to the hospital. Better biomarkers are needed to predict these outcomes. We performed metabolomic analyses of serum samples from patients with
Gaetano Isola et al.
Journal of periodontology (2020-01-09)
Asymmetric dimethylarginine (ADMA) plays a crucial role in endothelial function and maybe a link for the known interaction of periodontitis and coronary heart disease (CHD). In this pilot study, we compared the impact of gingival health, periodontitis (CP), CHD, or
Tse-Min Lu et al.
Atherosclerosis, 254, 161-166 (2016-10-17)
Decreased nitric oxide (NO) bioavailability and increased oxidative stress may be involved in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The relationship between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and CI-AKI is unknown. We measured plasma ADMA
Monitoring of L-Arginine and Endogenous Dimethylarginines in Survivor Septic Patients-A Pilot Study
Nemeth B, et al.
In Vivo, 30(5), 663-669 (2016)
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