D4268
NG,NG-二甲基精氨酸 二盐酸盐
≥98% (TLC), powder, NOS inhibitor
别名:
不对称-二甲基精氨酸, ADMA
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关于此项目
经验公式（希尔记法）:
C8H18N4O2 · 2HCl
化学文摘社编号:
分子量:
275.18
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.77
产品名称
NG,NG-二甲基精氨酸 二盐酸盐,
方案
≥98% (TLC)
质量水平
表单
powder
溶解性
water: 50 mg/mL, clear, colorless
储存温度
room temp
SMILES字符串
Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O
InChI
1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
InChI key
SYLNVYJOPZWPJI-ILKKLZGPSA-N
基因信息
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
一般描述
N G 、 N G -二甲基精氨酸二盐酸盐是一种甲基化精氨酸衍生物，由肝脏产生。与肝硬化、酒精性肝炎和急性肝衰竭 (ALF) 有关。
应用
NG,NG-二甲基精氨酸二盐酸盐曾被用于：
- 研究其对大鼠头端延髓腹外侧区(RVLM) 心血管活动的影响
- ，作为测量L-精氨酸和二甲基精氨酸的标准
- 来研究其对肝脏恶化的影响
生化/生理作用
体内和体外可逆的一氧化氮合成酶抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Aleksandar Radujkovic et al.
Haematologica, 104(4), 827-834 (2018-12-06)
Increasing evidence suggests that endothelial cell distress is associated with mortality after allogeneic stem cell transplantation and acute graft-versus-host disease. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that induces endothelial cell dysfunction. We analyzed the impact of pre-transplant
José D Martins et al.
Journal of the American Heart Association, 8(7), e011536-e011536 (2019-04-02)
Background Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE-COARCT (Long-term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment)
Marie Rodling Wahlström et al.
SpringerPlus, 3, 98-98 (2014-03-07)
A prospective, randomised, double-blinded, clinical trial was performed at a level 1 trauma centre to determine if a prostacyclin analogue, epoprostenol (Flolan®), could attenuate systemic inflammatory response in patients with severe traumatic brain injury (TBI). 46 patients with severe TBI
Kyoung Min Kim et al.
Cardiovascular diabetology, 16(1), 146-146 (2017-11-11)
The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20 mg rosuvastatin on biomarkers, including paraoxonase-1 (PON-1) and asymmetric dimethylarginine (ADMA), and on microvascular
Monitoring of L-Arginine and Endogenous Dimethylarginines in Survivor Septic Patients-A Pilot Study
Nemeth B, et al.
In Vivo, 30(5), 663-669 (2016)
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