D4268
NG,NG-二甲基精氨酸 二盐酸盐
≥98% (TLC), powder, NOS inhibitor
别名:
不对称-二甲基精氨酸, ADMA
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关于此项目
经验公式（希尔记法）:
C8H18N4O2 · 2HCl
化学文摘社编号:
分子量:
275.18
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
NG,NG-二甲基精氨酸 二盐酸盐,
assay
≥98% (TLC)
Quality Level
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
room temp
SMILES string
Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O
InChI
1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
InChI key
SYLNVYJOPZWPJI-ILKKLZGPSA-N
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
General description
N G 、 N G -二甲基精氨酸二盐酸盐是一种甲基化精氨酸衍生物，由肝脏产生。与肝硬化、酒精性肝炎和急性肝衰竭 (ALF) 有关。
Application
NG,NG-二甲基精氨酸二盐酸盐曾被用于：
- 研究其对大鼠头端延髓腹外侧区(RVLM) 心血管活动的影响
- ，作为测量L-精氨酸和二甲基精氨酸的标准
- 来研究其对肝脏恶化的影响
Biochem/physiol Actions
体内和体外可逆的一氧化氮合成酶抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
Aleksandar Radujkovic et al.
Haematologica, 104(4), 827-834 (2018-12-06)
Increasing evidence suggests that endothelial cell distress is associated with mortality after allogeneic stem cell transplantation and acute graft-versus-host disease. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that induces endothelial cell dysfunction. We analyzed the impact of pre-transplant
José D Martins et al.
Journal of the American Heart Association, 8(7), e011536-e011536 (2019-04-02)
Background Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE-COARCT (Long-term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment)
Gaetano Isola et al.
Journal of periodontology (2020-01-09)
Asymmetric dimethylarginine (ADMA) plays a crucial role in endothelial function and maybe a link for the known interaction of periodontitis and coronary heart disease (CHD). In this pilot study, we compared the impact of gingival health, periodontitis (CP), CHD, or
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D4268-50MG | 04061833564233 |
| D4268-10MG | 04061833564226 |