D4268
NG,NG-二甲基精氨酸 二盐酸盐
≥98% (TLC), powder, NOS inhibitor
别名:
不对称-二甲基精氨酸, ADMA
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关于此项目
经验公式（希尔记法）:
C8H18N4O2 · 2HCl
CAS Number:
分子量:
275.18
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.77
Product Name
NG,NG-二甲基精氨酸 二盐酸盐,
方案
≥98% (TLC)
质量水平
表单
powder
溶解性
water: 50 mg/mL, clear, colorless
储存温度
room temp
SMILES字符串
Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O
InChI
1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
InChI key
SYLNVYJOPZWPJI-ILKKLZGPSA-N
基因信息
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
一般描述
N G 、 N G -二甲基精氨酸二盐酸盐是一种甲基化精氨酸衍生物，由肝脏产生。与肝硬化、酒精性肝炎和急性肝衰竭 (ALF) 有关。
应用
NG,NG-二甲基精氨酸二盐酸盐曾被用于：
- 研究其对大鼠头端延髓腹外侧区(RVLM) 心血管活动的影响
- ，作为测量L-精氨酸和二甲基精氨酸的标准
- 来研究其对肝脏恶化的影响
生化/生理作用
体内和体外可逆的一氧化氮合成酶抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine
Okuyucu A, et al.
Turkish Journal of Biology, 40(2), 452-461 (2016)
Jasmohan S Bajaj et al.
Gastroenterology, 159(5), 1715-1730 (2020-07-21)
Inpatients with cirrhosis have high rates of acute-on-chronic failure (ACLF) development and high mortality within 30 days of admission to the hospital. Better biomarkers are needed to predict these outcomes. We performed metabolomic analyses of serum samples from patients with
Tse-Min Lu et al.
Atherosclerosis, 254, 161-166 (2016-10-17)
Decreased nitric oxide (NO) bioavailability and increased oxidative stress may be involved in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The relationship between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and CI-AKI is unknown. We measured plasma ADMA
Gaetano Isola et al.
Journal of periodontology (2020-01-09)
Asymmetric dimethylarginine (ADMA) plays a crucial role in endothelial function and maybe a link for the known interaction of periodontitis and coronary heart disease (CHD). In this pilot study, we compared the impact of gingival health, periodontitis (CP), CHD, or
Aleksandar Radujkovic et al.
Haematologica, 104(4), 827-834 (2018-12-06)
Increasing evidence suggests that endothelial cell distress is associated with mortality after allogeneic stem cell transplantation and acute graft-versus-host disease. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that induces endothelial cell dysfunction. We analyzed the impact of pre-transplant
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