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Merck
CN

D4297

脱氧胆酸

BioXtra, ≥98% (HPLC)

别名:

3α,12α-二羟基-5β-胆甾烯酸, 7-脱氧胆酸, 脱氧胆酸

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关于此项目

经验公式（希尔记法）:
C24H40O4
化学文摘社编号:
83-44-3
分子量:
392.57
EC Number:
201-478-5
UNSPSC Code:
12161900
PubChem Substance ID:
24893857
Beilstein/REAXYS Number:
3219882
MDL number:
MFCD00003673

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产品名称

脱氧胆酸, BioXtra, ≥98% (HPLC)

InChI key

KXGVEGMKQFWNSR-LLQZFEROSA-N

InChI

1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

biological source

bovine bile (ex gall bladder)

description

anionic

product line

BioXtra

assay

≥98% (HPLC)

form

powder

mol wt

micellar avg mol wt 1200-5000

aggregation number

3-12

impurities

≤0.005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

CMC

2-6

mp

171-174 °C (lit.)

cation traces

Al: ≤0.001%
Ca: ≤0.01%
Cu: ≤0.0005%
Fe: ≤0.005%
K: ≤0.005%
Mg: ≤0.005%
NH4+: ≤0.05%
Na: ≤0.02%
Pb: ≤0.001%
Zn: ≤0.0005%

HLB

16

functional group

carboxylic acid

shipped in

ambient

storage temp.

room temp

Gene Information

human ... ATIC(471)

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Application

脱氧胆酸已被用于一项研究中，以评估熊去氧胆酸（UDCA）与脱氧胆酸（DCA）的生理浓度如何影响小鼠肠道组织的屏障功能。 它也已被用于一项研究中，以表征肝脏破坏细胞色素p450（CYP）氧化还原酶基因小鼠模型中的胆汁形成。

General description

脱氧胆酸是可能影响细胞内信号转导和基因表达的一种胆汁酸。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
062K16631V
062K16631
SLBK3902V
038K0144
127K01231

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Cindy Kunne et al.
Hepatology (Baltimore, Md.), 57(4), 1509-1517 (2012-11-28)
The difference in bile salt (BS) composition between rodents and humans is mainly caused by formation of muricholate in rodents as well as by efficient rehydroxylation of deoxycholic acid. The aim of this study was to characterize bile formation in
Ying Kong et al.
The international journal of biochemistry & cell biology, 44(12), 2321-2332 (2012-08-21)
There is evidence indicating that bile acid is a promoter of colorectal cancer. Deoxycholic acid modifies apoptosis and proliferation by affecting intracellular signaling and gene expression. We are interested in revealing the relationship between deregulated miRNAs and deoxycholic acid in
Kunihiko Nishino et al.
Antimicrobial agents and chemotherapy, 54(5), 2239-2243 (2010-03-10)
NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps
Jeffery L Smith et al.
Hepatology (Baltimore, Md.), 39(6), 1673-1682 (2004-06-09)
Focal biliary cirrhosis causes significant morbidity and mortality in cystic fibrosis (CF). Although the mechanisms of pathogenesis remain unclear, bile acids have been proposed as potential mediators of liver injury. This study examined bile acid composition in CF and assessed
J Stadler et al.
Cancer letters, 38(3), 315-320 (1988-01-01)
Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous
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Product Information Sheet - D4297

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