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Merck
CN

D4438

Sigma-Aldrich

β-Dendrotoxin

≥98% (SDS-PAGE), lyophilized powder

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MDL编号:
UNSPSC代码:
12352200
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质量水平

方案

≥98% (SDS-PAGE)

表单

lyophilized powder

分子量

7,000 Da

储存温度

−20°C

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

制备说明

Purified by a modification of the method of Benishin.
Reconstitute in 1 mL deionized water or buffer to yield 5 μM stock.

其他说明

Major toxin from Dendroaspis angusticeps venom

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number

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J Ren et al.
The Journal of pharmacology and experimental therapeutics, 269(1), 209-214 (1994-04-01)
beta-Dendrotoxin (beta-DTX), a polypeptide component of Eastern Green Mamba snake venom, inhibits a slow voltage-activated 86Rb efflux from synaptosomes, suggesting that beta-DTX inhibits K+ channels. The effects of beta-DTX on the K+ currents in primary cultured and subcultured (passages 8-12)
C G Benishin et al.
Molecular pharmacology, 34(2), 152-159 (1988-08-01)
Venom from the green mamba (Dendroaspis angusticeps) blocked 86Rb efflux through voltage-gated K channels in rat brain synaptosomes. Crude venom inhibited both rapidly inactivating, 4-aminopyridine-sensitive K channels, and noninactivating, phencyclidine-sensitive, K channels. Fractionation of the venom by size exclusion chromatography

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