D4921
Destruxin A from Metarrhizium anisopliae
≥98% (HPLC)
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关于此项目
经验公式（希尔记法）:
C29H47N5O7
化学文摘社编号:
分子量:
577.71
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Destruxin A from Metarrhizium anisopliae, ≥98% (HPLC)
InChI
1S/C29H47N5O7/c1-9-12-21-27(38)34-16-11-13-20(34)26(37)31-23(18(5)10-2)28(39)33(8)24(17(3)4)29(40)32(7)19(6)25(36)30-15-14-22(35)41-21/h9,17-21,23-24H,1,10-16H2,2-8H3,(H,30,36)(H,31,37)/t18-,19-,20+,21-,23-,24-/m0/s1
SMILES string
CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC=C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O
InChI key
XIYSEKITPHTMJT-UTJJDKHZSA-N
biological source
Metarrhizium anisopliae
assay
≥98% (HPLC)
form
powder
storage temp.
−20°C
Quality Level
Analysis Note
Balance is other destruxins
Application
Destruxin A from Metarrhizium anisopliae has been used for immersion and inoculation bioassay in Rhipicephalus (Boophilus) microplus. It has been used as a transport inhibitor in Drosophila melanogaster.
Biochem/physiol Actions
Destruxin A is a cyclic hexadepsipeptide produced by fungus causing paralysis and death in insects. May suppress the insect immune response. Possesses an inhibitory activity on leukemic cell proliferation, decreasing the number of cells in G2/M phase. It is virustatic against arboviruses.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
高风险级别生物产品--毒素类产品
此项目有
Stefan Hutwimmer et al.
Mycologia, 102(1), 1-10 (2010-02-03)
Nutritional conditions causing droplet exudation by Metarhizium anisopliae var. anisopliae were studied. Exudation in droplets occurred only on media with more than one carbon source and was highly dependent on the ratio of a well metabolized sugar such as trehalose
Esau Ruiz-Sanchez et al.
Toxicon : official journal of the International Society on Toxinology, 56(6), 1043-1051 (2010-07-31)
Destruxins, a family of cyclic peptides, are produced by various species of entomopathogenic fungi. These peptides have been shown to influence calcium-dependent processes in insect cell lines and tissues, such as skeletal muscles. To better understand the mechanism of action
Patrícia Silva Gôlo et al.
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, 20(4), 338-341 (2011-12-15)
This study evaluated the effects of destruxin A on Rhipicephalus (Boophilus) microplus females, since this toxin is one of the likely causes of high mortality induced by the entomopathogenic fungus Metarhizium anisopliae in arthropods. Ticks were immersed or inoculated with
Xiang Meng et al.
Toxicon : official journal of the International Society on Toxinology, 58(4), 327-335 (2011-07-02)
The cytotoxicity of a destruxin A (DA) treatment of Spodoptera litura SL-1 cells was investigated. An MTT assay showed that DA was highly toxic to SL-1 cells in a concentration- and time-dependent manner. The IC(50) values of DA, after 24 h
Kopecky, J., et al.
Comparative Biochemistry and Physiology, 103C, 23-23 (1992)
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