D4921
Destruxin A from Metarrhizium anisopliae
≥98% (HPLC)
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关于此项目
经验公式（希尔记法）:
C29H47N5O7
化学文摘社编号:
分子量:
577.71
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C29H47N5O7/c1-9-12-21-27(38)34-16-11-13-20(34)26(37)31-23(18(5)10-2)28(39)33(8)24(17(3)4)29(40)32(7)19(6)25(36)30-15-14-22(35)41-21/h9,17-21,23-24H,1,10-16H2,2-8H3,(H,30,36)(H,31,37)/t18-,19-,20+,21-,23-,24-/m0/s1
SMILES string
CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC=C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O
InChI key
XIYSEKITPHTMJT-UTJJDKHZSA-N
biological source
Metarrhizium anisopliae
assay
≥98% (HPLC)
form
powder
storage temp.
−20°C
Quality Level
Application
Destruxin A from Metarrhizium anisopliae has been used for immersion and inoculation bioassay in Rhipicephalus (Boophilus) microplus. It has been used as a transport inhibitor in Drosophila melanogaster.
Biochem/physiol Actions
Destruxin A is a cyclic hexadepsipeptide produced by fungus causing paralysis and death in insects. May suppress the insect immune response. Possesses an inhibitory activity on leukemic cell proliferation, decreasing the number of cells in G2/M phase. It is virustatic against arboviruses.
Analysis Note
Balance is other destruxins
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
高风险级别生物产品--毒素类产品
此项目有
Stefan Hutwimmer et al.
Mycologia, 102(1), 1-10 (2010-02-03)
Nutritional conditions causing droplet exudation by Metarhizium anisopliae var. anisopliae were studied. Exudation in droplets occurred only on media with more than one carbon source and was highly dependent on the ratio of a well metabolized sugar such as trehalose
Qiong-Bo Hu et al.
Toxicon : official journal of the International Society on Toxinology, 48(5), 491-498 (2006-09-08)
The production levels of destruxin A and B (DA and DB) of 80 Metarhizium strains from China were investigated. The average yields of DA and DB were 14.87+/-2.30 and 3.65+/-0.58 microg/mL, respectively. The strains isolated from soil had significantly (p<0.05)
Esau Ruiz-Sanchez et al.
Archives of insect biochemistry and physiology, 80(2), 109-122 (2012-04-24)
Destruxins have been implicated in the infection process by entomopathogenic fungi and have been also found to be highly toxic when applied topically or ingested by different insect species. To gain insight into the mechanism of action of this toxin
Esau Ruiz-Sanchez et al.
Toxicon : official journal of the International Society on Toxinology, 55(6), 1162-1170 (2010-01-12)
The production of peptide toxins by entomopathogenic fungi during the infection process plays critical roles in pathogenesis. To gain insight into the mechanism of action of these mycotoxins on insect internal organs, we have evaluated the effects of destruxin A
Xiang Meng et al.
Toxicon : official journal of the International Society on Toxinology, 58(4), 327-335 (2011-07-02)
The cytotoxicity of a destruxin A (DA) treatment of Spodoptera litura SL-1 cells was investigated. An MTT assay showed that DA was highly toxic to SL-1 cells in a concentration- and time-dependent manner. The IC(50) values of DA, after 24 h
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