D5038
2′-脱氧鸟苷5′-三磷酸 三钠盐
100 mM (pH 7)
别名:
dGTP-Na3
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关于此项目
经验公式（希尔记法）:
C10H13N5Na3O13P3
CAS Number:
分子量:
573.13
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.52
方案
≥99%
质量水平
表单
liquid
浓度
100 mM (pH 7)
颜色
colorless
异质活性
DNase, RNase, none detected
运输
dry ice
储存温度
−20°C
SMILES字符串
[Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)O3)C(=O)N1
InChI
1S/C10H16N5O13P3.3Na/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17);;;/q;3*+1/p-3/t4-,5+,6+;;;/m0.../s1
InChI key
IWGGLKOTEOCWQP-BIHLCPNHSA-K
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相关类别
一般描述
2′-脱氧鸟苷5′-三磷酸(dGTP)的结构为鸟嘌呤碱基连接脱氧核糖，糖的5′-羟基位再连接三个磷酸残基链。可用于通过DNA聚合酶合成DNA。
应用
2′-脱氧鸟苷5′-三磷酸三钠盐可用于DNA测序、PCR和其他基于DNA聚合酶的DNA合成和修复技术。
2′-Deoxyguanosine 5′-triphosphate trisodium salt solution has been used:
- in a reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification.
- as a component of the PCR mix for in situ reverse transcription-polymerase chain reaction (RT-PCR) amplification of mRNA from prokaryotic and eukaryotic ribosomes
- to study the mutations in the HBB gene via amplification refractory mutation system (ARMS)-PCR
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Alex von Kriegsheim et al.
Methods in molecular biology (Clifton, N.J.), 484, 177-192 (2008-07-02)
Signaling pathways transduce extracellular stimuli from the membrane to the nucleus. Constitutive and thus inappropriate stimulation of these kinase cascades is associated with and observed in a majority of tumors. The transduction of signals in these pathways is achieved through
Functional Protein Microarrays in Drug Discovery (2008)
Analysis of beta globin gene mutations in Diyarbakir
Tekecs S, et al.
Turkish Journal of Biology (2021)
Marco Gatti et al.
Cell reports, 32(5), 107985-107985 (2020-08-07)
PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in homology-directed repair (HDR) is not well understood. Here, we identify the ubiquitin E3 ligase TRIP12 as negative regulator
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