biological source
synthetic
Quality Segment
form
powder
color
dark red-purple to black
solubility
ethanol: ~10 mg/mL (lit.), DMSO: >25 mg/mL (lit.)
antibiotic activity spectrum
neoplastics
mode of action
protein synthesis | interferes
storage temp.
−20°C
General description
Chemical structure: benzenoid
Application
17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC).
Biochem/physiol Actions
17-DMAG is a heat shock protein (HSP90) inhibitor. 17-DMAG is a more potent analog of geldanamycin. It inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.
17-DMAG is a more potent analog of geldanamycin. Inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable