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D5297

Dehydroisoandrosterone 3-sulfate sodium salt dihydrate

Name: Dehydroisoandrosterone 3-sulfate sodium salt dihydrate
Brand: SIGMA

≥93% (TLC), GABAA modulator, powder

别名:

5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate, Prasterone sulfate sodium salt dihydrate, Sodium dehydroepiandrosterone sulfate

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经验公式（希尔记法）:

C₁₉H₂₇NaO₅S · 2H₂O

化学文摘社编号:

78590-17-7

分子量:

426.50

NACRES:

NA.77

PubChem Substance ID:

24278373

UNSPSC Code:

12352200

EC Number:

214-152-2

MDL number:

MFCD11045975

Assay:

≥93% (TLC)

Form:

powder

Quality level:

200

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属性

产品名称

Dehydroisoandrosterone 3-sulfate sodium salt dihydrate, ≥93% (TLC), powder

Quality Level

200

assay

≥93% (TLC)

form

powder

drug control

Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to off-white

mp

148-149 °C (dec.) (lit.)

solubility

methanol: soluble, clear to hazy

SMILES string

O.O.[Na+].C[C@]12CC[C@H]3[C@@H](CC=C4C[C@H](CC[C@]34C)OS([O-])(=O)=O)[C@@H]1CCC2=O

InChI

1S/C19H28O5S.Na.2H2O/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18;;;/h3,13-16H,4-11H2,1-2H3,(H,21,22,23);;2*1H2/q;+1;;/p-1/t13-,14-,15-,16-,18-,19-;;;/m0.../s1

InChI key

NLNMKDUYGPNWAO-OXNWJOIVSA-M

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

说明

Application

Dehydroisoandrosterone 3-sulfate sodium salt dihydrate has been used as a supplement to induce superoxide anion production in human neutrophil granulocytes.

Biochem/physiol Actions

Dehydroisoandrosterone 3-sulfate sodium salt dihydrate is a negative allosteric modulator of GABA_A receptors.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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商品

GABAA Receptors

We offer many products related to GABAA receptors for your research needs.

DISCOVER Bioactive Small Molecules for Neuroscience

Differential blockade of gamma-aminobutyric acid type A receptors by the neuroactive steroid dehydroepiandrosterone sulfate in posterior and intermediate pituitary.

S L Hansen et al.

Molecular pharmacology, 55(3), 489-496 (1999-03-03)

Dehydroepiandrosterone sulfate (DHEAS) is a neuroactive steroid with antagonist action at gamma-aminobutyric acid type A (GABAA) receptors. Patch-clamp techniques were used to investigate DHEAS actions at GABAA receptors of the rat pituitary gland at two distinct loci: posterior pituitary nerve

Plasma concentration of myeloperoxidase enzyme in pre-and post-climacterial people: related superoxide anion generation

Bekesi G, et al.

Experimental Gerontology, 37(1), 137-148 (2001)

Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors.

P A Lapchak et al.

Stroke, 31(8), 1953-1956 (2000-08-06)

Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) may function as neurotrophic or neuroprotective factors to protect central nervous system (CNS) neurons against a variety of insults, including excitotoxicity. The present study evaluated the pharmacological effects of DHEAS in a reversible spinal

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全球贸易项目编号

货号	GTIN
D5297-1G	04061833586143
D5297-10G	04061832090481
D5297-250MG	04061833586150