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GABRB3

gamma-aminobutyric acid (GABA) A receptor, beta 3

Synonyms:
ECA5
Species:
UniProtKB ID:
Gene ID:
  • Human(2562) Summary: This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
  • Mouse(14402) gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
  • Rat(24922) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • Zebrafish(566922) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • chicken(396290) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • Horse(100050803) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • cow(529593) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • dog(606913) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • sheep(101114905) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • domestic cat(100286790) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • domestic guinea pig(100731340) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • naked mole-rat(101711687) gamma-aminobutyric acid (GABA) A receptor, beta 3

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Small Molecule - Agonist

Product Number
Description
Species
Gaboxadol hydrochloride, solid, ≥98% (HPLC),
Species
human
Muscimol hydrobromide, ≥98% (HPLC), solid,
Species
human
Piperidine-4-sulfonic acid, ,
Species
human
γ-Aminobutyric acid, ≥99%,
Species
human, rat
2-Bromo-2-chloro-1,1,1-trifluoroethane, ≥99%,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Etazolate hydrochloride, solid,
Species
human
trans-Dehydroandrosterone, ≥99%,
Species
human, rat
Propofol, British Pharmacopoeia (BP) Reference Standard,
Species
human
Thiopental, United States Pharmacopeia (USP) Reference Standard,
Species
human
Propofol, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
SR-95531, ≥98% (HPLC), powder,
Species
human
trans-Dehydroandrosterone, ≥99%,
Species
human, rat
Flumazenil, United States Pharmacopeia (USP) Reference Standard,
Species
human
Ganaxolone, solid, ≥98% (HPLC),
Species
human, mouse
2,6-Diisopropylphenol, 97%,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GABRB3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
Anti-GABRB3 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
immunohistochemistry
Monoclonal Anti-GABRB3 antibody produced in mouse, clone S87-25, 1 mg/mL, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Etazolate hydrochloride, solid,
Species
human
NO-711 hydrochloride, ≥98% (HPLC),
Species
human
(±)-Vigabatrin, ,
Species
human
2,6-Diisopropylphenol, 97%,
Species
human
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
2-Bromo-2-chloro-1,1,1-trifluoroethane, ≥99%,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GABRB3,
Species
human