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文件

COO原产地证书/COA分析证书

D5314

DPQ

Name: DPQ
Brand: SIGMA

≥98% (HPLC), solid

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别名:

3,4-二氢-5- [4-(1-哌啶基)丁氧基] -1(2H)-异喹啉酮

经验公式（希尔记法）:

C₁₈H₂₆N₂O₂

CAS号:

129075-73-6

分子量:

302.41

MDL编号:

MFCD01866274

NACRES:

NA.77

生物来源

synthetic (organic)

质量水平

200

检测方案

≥98% (HPLC)

形式

solid

mp

107-109 °C

溶解性

DMSO: 1 mg/mL, clear, colorless to faintly yellow

储存温度

2-8°C

InChI

1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)

InChI key

RVOUDNBEIXGHJY-UHFFFAOYSA-N

应用

在体内研究中，DPQ已被用作一种PARP 1（聚(ADP-核糖)聚合酶1）抑制剂，用于确定辐照后γ-H2AX（H2A组蛋白家族成员X）的损失。

生化/生理作用

在局部缺血的影响下，已知3,4-二氢-5-[4-(1-哌啶基)丁氧基]-1(2H)-异喹啉酮（DPQ）可降低PARP 1（聚(ADP-核糖)聚合酶1）介导的细胞凋亡。它被认为是比传统使用的PARP1抑制剂3-氨基苯甲酰胺更有效的抑制剂。

DPQ是一种非常有效的聚(ADP-核糖)聚合酶（PARP）抑制剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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1000309185

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DPQ