D5314
DPQ
≥98% (HPLC), solid
别名:
3,4-二氢-5- [4-(1-哌啶基)丁氧基] -1(2H)-异喹啉酮
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关于此项目
经验公式（希尔记法）:
C18H26N2O2
化学文摘社编号:
分子量:
302.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
DPQ, ≥98% (HPLC), solid
form
solid
SMILES string
N3(CCCCC3)CCCCOc1c2c(ccc1)C(=O)NCC2
InChI
1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
InChI key
RVOUDNBEIXGHJY-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥98% (HPLC)
mp
107-109 °C
solubility
DMSO: 1 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
相关类别
Application
在体内研究中，DPQ已被用作一种PARP 1（聚(ADP-核糖)聚合酶1）抑制剂，用于确定辐照后γ-H2AX（H2A组蛋白家族成员X）的损失。
Biochem/physiol Actions
DPQ是一种非常有效的聚(ADP-核糖)聚合酶（PARP）抑制剂。
在局部缺血的影响下，已知3,4-二氢-5-[4-(1-哌啶基)丁氧基]-1(2H)-异喹啉酮（DPQ）可降低PARP 1（聚(ADP-核糖)聚合酶1）介导的细胞凋亡。它被认为是比传统使用的PARP1抑制剂3-氨基苯甲酰胺更有效的抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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