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D5564

7,8-Dihydroxycoumarin

Name: 7,8-Dihydroxycoumarin
Brand: SIGMA

≥97%, powder

别名:

Daphnetin, Daphnetol, Ruixiangsu

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关于此项目

经验公式（希尔记法）:

C₉H₆O₄

化学文摘社编号:

486-35-1

分子量:

178.14

NACRES:

NA.77

PubChem Substance ID:

24278375

UNSPSC Code:

12352200

EC Number:

207-632-8

MDL number:

MFCD00016977

Assay:

≥97%

Form:

powder

Quality level:

200

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biological source

synthetic (organic)

Quality Level

200

assay

≥97%

form

powder

solubility

ethanol: 5 mg/mL

storage temp.

room temp

SMILES string

Oc1ccc2C=CC(=O)Oc2c1O

InChI

1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H

InChI key

ATEFPOUAMCWAQS-UHFFFAOYSA-N

Biochem/physiol Actions

7,8-Dihydroxycoumarinan is an inhibitor of protein kinases. It is an active lactone present in plants such as Daphne Korean Nakai, and Thymelaeaceae Daphne. It serves as as analgesic, antiviral and antibacterial agent. 7,8-Dihydroxycoumarinan is found to induce tumor apoptosis via a number of signalling pathways. Thus, it is believed to exhibit antitumor effects. 7,8-Dihydroxycoumarinan might also be useful in treating lung carcinoma. It is also known to be used in treating coagulation disorders and rheumatoid arthritis. 7,8-Dihydroxycoumarinan is known to induce neurite growth and lengthen neuronal survival. It helps in clearing substances inducing necrosis, maintains water-electrolytes balance and energy metabolism. 7,8-Dihydroxycoumarinan is involved in the generation of neurotrophic factor and helps in restoring neuron function.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000469678

0000461099

0000367121

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7, 8-Dihydroxycoumarin inhibits A549 human lung adenocarcinoma cell proliferation by inducing apoptosis via suppression of AktNF-kappaB signaling

Wang Y, et al.

Experimental and Therapeutic Medicine, 5(6), 1770-1774 (2013)

Neurotrophic effects of 7,8-dihydroxycoumarin in primary cultured rat cortical neurons

Yan L, et al.

Experimental and Therapeutic Medicine, 28(5), 493?498-493?498 (2012)

Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor.

E B Yang et al.

Biochemical and biophysical research communications, 260(3), 682-685 (1999-07-15)

Protein kinases play key roles in the control of cell proliferation, differentiation and metabolism. In this work, we studied the effect of coumarin and its derivatives, including daphnetin, esculin, 2-OH-coumarin, 4-OH-coumarin and 7-OH-coumarin, on the activity of protein kinases. It

Binding of the bioactive component daphnetin to human serum albumin demonstrated using tryptophan fluorescence quenching.

Jiaqin Liu et al.

Macromolecular bioscience, 4(5), 520-525 (2004-10-07)

Daphnetin (7,8-dihydroxycoumarin), one of the major bioactive components isolated from Daphne koreane Nakai, has been used in traditional Chinese medicine for the treatment of coagulation disorders. It is also a chelator, an antioxidant and a protein kinase inhibitor. In this

Regulatory effect of daphnetin, a coumarin extracted from Daphne odora, on the balance of Treg and Th17 in collagen-induced arthritis.

Rongfeng Yao et al.

European journal of pharmacology, 670(1), 286-294 (2011-09-15)

Daphnetin extracted from Daphne odora Var. marginata contains coumarin compounds, which possess properties of analgesic and anti-inflammatory effects. In this study, we investigated the therapeutic effect of daphnetin on anti-arthritis and its role on the balance of Tregs and Th17

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全球贸易项目编号

货号	GTIN
D5564-5MG	04061832434018
D5564-25MG	04061832434001

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